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Gene Review

Nnc1  -  neuron number control 1

Mus musculus

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Disease relevance of Nnc1

  • Our analysis indicates that substitutions of single alleles at the Nnc1 locus are responsible for production differences of approximately 8000 ganglion cells [1].

High impact information on Nnc1


Biological context of Nnc1


  1. Cell production and cell death in the generation of variation in neuron number. Strom, R.C., Williams, R.W. J. Neurosci. (1998) [Pubmed]
  2. Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. Williams, R.W., Strom, R.C., Goldowitz, D. J. Neurosci. (1998) [Pubmed]
  3. Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice. Zhou, G., Strom, R.C., Giguere, V., Williams, R.W. Mol. Vis. (2001) [Pubmed]
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