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Gene Review

BIRC8  -  baculoviral IAP repeat containing 8

Homo sapiens

Synonyms: Baculoviral IAP repeat-containing protein 8, IAP-like protein 2, ILP-2, ILP2, Inhibitor of apoptosis-like protein 2, ...
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Disease relevance of BIRC8


High impact information on BIRC8


Anatomical context of BIRC8

  • Despite high homology to ILP-1, ILP-2 is encoded by a distinct gene, which in normal tissues is expressed solely in testis [2].


  1. Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia. Abe, S., Yamamoto, K., Hasegawa, M., Inoue, M., Kurata, M., Hirokawa, K., Kitagawa, M., Nakagawa, Y., Suzuki, K. Leuk. Res. (2005) [Pubmed]
  2. Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Richter, B.W., Mir, S.S., Eiben, L.J., Lewis, J., Reffey, S.B., Frattini, A., Tian, L., Frank, S., Youle, R.J., Nelson, D.L., Notarangelo, L.D., Vezzoni, P., Fearnhead, H.O., Duckett, C.S. Mol. Cell. Biol. (2001) [Pubmed]
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