Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

BIRC8 - baculoviral IAP repeat containing 8

Homo sapiens

Synonyms: Baculoviral IAP repeat-containing protein 8, IAP-like protein 2, ILP-2, ILP2, Inhibitor of apoptosis-like protein 2, ...

Richter, B.W. et al., Abe, S. et al.

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Disease relevance of BIRC8

Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia [1].

High impact information on BIRC8

In contrast to ILP-1, overexpression of ILP-2 had no protective effect on apoptosis mediated by Fas (also known as CD95) or tumor necrosis factor [2].
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family [2].

Anatomical context of BIRC8

Despite high homology to ILP-1, ILP-2 is encoded by a distinct gene, which in normal tissues is expressed solely in testis [2].

References

Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia. Abe, S., Yamamoto, K., Hasegawa, M., Inoue, M., Kurata, M., Hirokawa, K., Kitagawa, M., Nakagawa, Y., Suzuki, K. Leuk. Res. (2005) [Pubmed]
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Richter, B.W., Mir, S.S., Eiben, L.J., Lewis, J., Reffey, S.B., Frattini, A., Tian, L., Frank, S., Youle, R.J., Nelson, D.L., Notarangelo, L.D., Vezzoni, P., Fearnhead, H.O., Duckett, C.S. Mol. Cell. Biol. (2001) [Pubmed]

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