Gene Review:
XIAP - X-linked inhibitor of apoptosis, E3...
Homo sapiens
Synonyms:
API3, BIRC4, Baculoviral IAP repeat-containing protein 4, E3 ubiquitin-protein ligase XIAP, IAP-3, ...
- Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. Fu, J., Jin, Y., Arend, L.J. J. Biol. Chem. (2003)
- X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. Takeuchi, H., Kim, J., Fujimoto, A., Umetani, N., Mori, T., Bilchik, A., Turner, R., Tran, A., Kuo, C., Hoon, D.S. Clin. Cancer Res. (2005)
- Acquired TRAIL resistance in human breast cancer cells are caused by the sustained cFLIP(L) and XIAP protein levels and ERK activation. Lee, T.J., Lee, J.T., Park, J.W., Kwon, T.K. Biochem. Biophys. Res. Commun. (2006)
- Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma. Wagenknecht, B., Glaser, T., Naumann, U., Kügler, S., Isenmann, S., Bähr, M., Korneluk, R., Liston, P., Weller, M. Cell Death Differ. (1999)
- Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Christie, L.A., Su, J.H., Tu, C.H., Dick, M.C., Zhou, J., Cotman, C.W. Neurobiol. Dis. (2007)
- A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Srinivasula, S.M., Hegde, R., Saleh, A., Datta, P., Shiozaki, E., Chai, J., Lee, R.A., Robbins, P.D., Fernandes-Alnemri, T., Shi, Y., Alnemri, E.S. Nature (2001)
- X-linked IAP is a direct inhibitor of cell-death proteases. Deveraux, Q.L., Takahashi, R., Salvesen, G.S., Reed, J.C. Nature (1997)
- XIAP, the guardian angel. Holcik, M., Korneluk, R.G. Nat. Rev. Mol. Cell Biol. (2001)
- XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. Mufti, A.R., Burstein, E., Csomos, R.A., Graf, P.C., Wilkinson, J.C., Dick, R.D., Challa, M., Son, J.K., Bratton, S.B., Su, G.L., Brewer, G.J., Jakob, U., Duckett, C.S. Mol. Cell (2006)
- Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. Liu, X., Shi, Y., Giranda, V.L., Luo, Y. Mol. Cancer Ther. (2006)
- Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Silke, J., Kratina, T., Chu, D., Ekert, P.G., Day, C.L., Pakusch, M., Huang, D.C., Vaux, D.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP. Kim, E.H., Kim, S.U., Shin, D.Y., Choi, K.S. Oncogene (2004)
- Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. Kim, E.H., Kim, S.U., Choi, K.S. Oncogene (2005)
- Sodium butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. Kim, E.H., Kim, H.S., Kim, S.U., Noh, E.J., Lee, J.S., Choi, K.S. Oncogene (2005)
- Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript. Lagacé, M., Xuan, J.Y., Young, S.S., McRoberts, C., Maier, J., Rajcan-Separovic, E., Korneluk, R.G. Genomics (2001)
- Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells. Nomura, T., Yamasaki, M., Nomura, Y., Mimata, H. Oncol. Rep. (2005)
- Role of XIAP protein, a human member of the inhibitor of apoptosis (IAP) protein family, in phytohemagglutinin-induced apoptosis of human T cell lines. Vitté-Mony, I., Korneluk, R.G., Diaz-Mitoma, F. Apoptosis (1997)
- Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation. Leverkus, M., Sprick, M.R., Wachter, T., Mengling, T., Baumann, B., Serfling, E., Bröcker, E.B., Goebeler, M., Neumann, M., Walczak, H. Mol. Cell. Biol. (2003)
- Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP. Gardai, S.J., Whitlock, B.B., Xiao, Y.Q., Bratton, D.B., Henson, P.M. J. Biol. Chem. (2004)
- Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. Huang, Y., Rich, R.L., Myszka, D.G., Wu, H. J. Biol. Chem. (2003)
- Effects of vitamin E on the cinnamaldehyde-induced apoptotic mechanism in human PLC/PRF/5 cells. Wu, S.J., Ng, L.T., Lin, C.C. Clin. Exp. Pharmacol. Physiol. (2004)
- The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2. Holcík, M., Gordon, B.W., Korneluk, R.G. Mol. Cell. Biol. (2003)
- The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. Eckelman, B.P., Salvesen, G.S. J. Biol. Chem. (2006)
- SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). Vucic, D., Deshayes, K., Ackerly, H., Pisabarro, M.T., Kadkhodayan, S., Fairbrother, W.J., Dixit, V.M. J. Biol. Chem. (2002)
- ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. Sanna, M.G., da Silva Correia, J., Luo, Y., Chuang, B., Paulson, L.M., Nguyen, B., Deveraux, Q.L., Ulevitch, R.J. J. Biol. Chem. (2002)
- Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. Liston, P., Fong, W.G., Kelly, N.L., Toji, S., Miyazaki, T., Conte, D., Tamai, K., Craig, C.G., McBurney, M.W., Korneluk, R.G. Nat. Cell Biol. (2001)
- The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. Martins, L.M., Iaccarino, I., Tenev, T., Gschmeissner, S., Totty, N.F., Lemoine, N.R., Savopoulos, J., Gray, C.W., Creasy, C.L., Dingwall, C., Downward, J. J. Biol. Chem. (2002)
- siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. Ohnishi, K., Scuric, Z., Schiestl, R.H., Okamoto, N., Takahashi, A., Ohnishi, T. Radiat. Res. (2006)
- XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. Yamaguchi, K., Nagai, S., Ninomiya-Tsuji, J., Nishita, M., Tamai, K., Irie, K., Ueno, N., Nishida, E., Shibuya, H., Matsumoto, K. EMBO J. (1999)
- Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation. Lin, M.T., Chang, C.C., Chen, S.T., Chang, H.L., Su, J.L., Chau, Y.P., Kuo, M.L. J. Biol. Chem. (2004)
- Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Liu, Z., Sun, C., Olejniczak, E.T., Meadows, R.P., Betz, S.F., Oost, T., Herrmann, J., Wu, J.C., Fesik, S.W. Nature (2000)
- The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Yu, C., Rahmani, M., Dai, Y., Conrad, D., Krystal, G., Dent, P., Grant, S. Cancer Res. (2003)
- Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. Davoodi, J., Lin, L., Kelly, J., Liston, P., MacKenzie, A.E. J. Biol. Chem. (2004)
- Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Byun, D.S., Cho, K., Ryu, B.K., Lee, M.G., Kang, M.J., Kim, H.R., Chi, S.G. Cancer Res. (2003)
- Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XIAP-associated factor 1. Perrelet, D., Perrin, F.E., Liston, P., Korneluk, R.G., MacKenzie, A., Ferrer-Alcon, M., Kato, A.C. J. Neurosci. (2004)
- XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. Scott, F.L., Denault, J.B., Riedl, S.J., Shin, H., Renatus, M., Salvesen, G.S. EMBO J. (2005)