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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PNKP  -  polynucleotide kinase 3'-phosphatase

Homo sapiens

Synonyms: Bifunctional polynucleotide phosphatase/kinase, DNA 5'-kinase/3'-phosphatase, EIEE10, MCSZ, PNK, ...
 
 
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High impact information on PNKP

  • This protein is composed of three domains that share distant homology with the amino-terminal domain of polynucleotide kinase 3'- phosphatase (PNKP), with histidine-triad (HIT) proteins and with DNA-binding C2H2 zinc-finger proteins, respectively [1].
  • ZmDP2 shares a partial amino acid sequence similarity with a recently identified human polynucleotide kinase 3'-phosphatase that is thought to be involved in DNA repair, but is devoid of 5'-kinase activity [2].
  • The 57.1-kDa conceptual translation product of this gene, polynucleotide kinase 3'-phosphatase (PNKP), contained a putative ATP binding site and a potential 3'-phosphatase domain with similarity to L-2-haloacid dehalogenases [3].
 

Analytical, diagnostic and therapeutic context of PNKP

  • Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage [3].

References

  1. The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Moreira, M.C., Barbot, C., Tachi, N., Kozuka, N., Uchida, E., Gibson, T., Mendonça, P., Costa, M., Barros, J., Yanagisawa, T., Watanabe, M., Ikeda, Y., Aoki, M., Nagata, T., Coutinho, P., Sequeiros, J., Koenig, M. Nat. Genet. (2001) [Pubmed]
  2. A plant 3'-phosphoesterase involved in the repair of DNA strand breaks generated by oxidative damage. Betti, M., Petrucco, S., Bolchi, A., Dieci, G., Ottonello, S. J. Biol. Chem. (2001) [Pubmed]
  3. Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. Jilani, A., Ramotar, D., Slack, C., Ong, C., Yang, X.M., Scherer, S.W., Lasko, D.D. J. Biol. Chem. (1999) [Pubmed]
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