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Gene Review:

OIP5 - Opa interacting protein 5

Homo sapiens

Synonyms: 5730547N13Rik, CT86, Cancer/testis antigen 86, LINT-25, MIS18B, ...

Nakamura, Y. et al.

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Disease relevance of OIP5

CONCLUSIONS: Using a combination of LMD and microarray, we identified OIP5 as a cancer-testis specific gene [1].
In 58 clinical cases of gastric cancer examined, we found OIP5 gene expression in 27 cases (47%) [1].

High impact information on OIP5

A human total RNA master panel demonstrated that OIP5, but not Exo1 or CDC6, showed high specificity in testis [1].

Analytical, diagnostic and therapeutic context of OIP5

The expression levels of selected genes, including OIP5, was confirmed by real time RT-PCR analysis in tumor/normal paired bulk samples of 58 clinical cases [1].
Further expression analysis in a set of clinical cases revealed that OIP5 may be a novel immunotherapy target for patients with gastric cancer [1].

References

Opa Interacting Protein 5 (OIP5) Is a Novel Cancer-testis Specific Gene in Gastric Cancer. Nakamura, Y., Tanaka, F., Nagahara, H., Ieta, K., Haraguchi, N., Mimori, K., Sasaki, A., Inoue, H., Yanaga, K., Mori, M. Ann. Surg. Oncol. (2007) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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