Gene Review:
CDC6 - cell division cycle 6
Homo sapiens
Synonyms:
CDC18L, CDC6-related protein, Cdc18-related protein, Cell division control protein 6 homolog, HsCDC18, ...
- Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer. Robles, L.D., Frost, A.R., Davila, M., Hutson, A.D., Grizzle, W.E., Chakrabarti, R. J. Biol. Chem. (2002)
- Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. Murphy, N., Ring, M., Heffron, C.C., Martin, C.M., McGuinness, E., Sheils, O., O'Leary, J.J. Mod. Pathol. (2005)
- Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector. Luo, F., Yee, J.K., Huang, S.H., Wu, L.T., Jong, A.Y. Methods Mol. Biol. (2006)
- Chapter 10: New dimensions in cervical cancer screening. Cuzick, J., Mayrand, M.H., Ronco, G., Snijders, P., Wardle, J. Vaccine (2006)
- CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Mailand, N., Diffley, J.F. Cell (2005)
- CDKs give Cdc6 a license to drive into S phase. Ayad, N.G. Cell (2005)
- Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Petersen, B.O., Wagener, C., Marinoni, F., Kramer, E.R., Melixetian, M., Lazzerini Denchi, E., Gieffers, C., Matteucci, C., Peters, J.M., Helin, K. Genes Dev. (2000)
- Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells. Takeda, D.Y., Shibata, Y., Parvin, J.D., Dutta, A. Genes Dev. (2005)
- Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. Fujita, M., Yamada, C., Goto, H., Yokoyama, N., Kuzushima, K., Inagaki, M., Tsurumi, T. J. Biol. Chem. (1999)
- CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex. Takayama, M., Taira, T., Iguchi-Ariga, S.M., Ariga, H. FEBS Lett. (2000)
- Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization. Bermejo, R., Vilaboa, N., Calés, C. Mol. Biol. Cell (2002)
- p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation. Duursma, A., Agami, R. Mol. Cell. Biol. (2005)
- Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis. Yim, H., Jin, Y.H., Park, B.D., Choi, H.J., Lee, S.K. Mol. Biol. Cell (2003)
- Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression. Yin, M.B., Li, Z.R., Cao, S., Durrani, F.A., Azrak, R.G., Frank, C., Rustum, Y.M. Mol. Pharmacol. (2004)
- Androgen receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase. Bai, V.U., Cifuentes, E., Menon, M., Barrack, E.R., Reddy, G.P. J. Cell. Physiol. (2005)
- Metazoan origin selection: origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis. Harvey, K.J., Newport, J. J. Biol. Chem. (2003)
- Differential binding of replication proteins across the human c-myc replicator. Ghosh, M., Kemp, M., Liu, G., Ritzi, M., Schepers, A., Leffak, M. Mol. Cell. Biol. (2006)
- Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication. Furstenthal, L., Kaiser, B.K., Swanson, C., Jackson, P.K. J. Cell Biol. (2001)
- PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Yan, Z., Fedorov, S.A., Mumby, M.C., Williams, R.S. Mol. Cell. Biol. (2000)
- Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A. Alexandrow, M.G., Hamlin, J.L. Mol. Cell. Biol. (2004)
- Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. Sugimoto, N., Tatsumi, Y., Tsurumi, T., Matsukage, A., Kiyono, T., Nishitani, H., Fujita, M. J. Biol. Chem. (2004)
- Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells. Yim, H., Hwang, I.S., Choi, J.S., Chun, K.H., Jin, Y.H., Ham, Y.M., Lee, K.Y., Lee, S.K. J. Cell Biol. (2006)
- Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Cook, J.G., Park, C.H., Burke, T.W., Leone, G., DeGregori, J., Engel, A., Nevins, J.R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. Hall, J.R., Kow, E., Nevis, K.R., Lu, C.K., Luce, K.S., Zhong, Q., Cook, J.G. Mol. Biol. Cell (2007)
- Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E. Sotillo, E., Garriga, J., Padgaonkar, A., Kurimchak, A., Cook, J.G., Graña, X. J. Biol. Chem. (2009)
- Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. Petersen, B.O., Lukas, J., Sørensen, C.S., Bartek, J., Helin, K. EMBO J. (1999)
- Localization of proteins bound to a replication origin of human DNA along the cell cycle. Abdurashidova, G., Danailov, M.B., Ochem, A., Triolo, G., Djeliova, V., Radulescu, S., Vindigni, A., Riva, S., Falaschi, A. EMBO J. (2003)
- Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Paolinelli, R., Mendoza-Maldonado, R., Cereseto, A., Giacca, M. Nat. Struct. Mol. Biol. (2009)
- Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Williams, G.H., Romanowski, P., Morris, L., Madine, M., Mills, A.D., Stoeber, K., Marr, J., Laskey, R.A., Coleman, N. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Yan, Z., DeGregori, J., Shohet, R., Leone, G., Stillman, B., Nevins, J.R., Williams, R.S. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Identification and functional analysis of a human homologue of the monkey replication origin ors8. Callejo, M., Sibani, S., Di Paola, D., Price, G.G., Zannis-Hadjopoulos, M. J. Cell. Biochem. (2006)