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Gene Review

CHRNA1  -  cholinergic receptor, nicotinic, alpha 1...

Homo sapiens

Synonyms: ACHRA, ACHRD, Acetylcholine receptor subunit alpha, CHNRA, CHRNA, ...
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Disease relevance of CHRNA1


High impact information on CHRNA1


Biological context of CHRNA1


  1. Human muscle acetylcholine receptor alpha-subunit gene (CHRNA1) association with autoimmune myasthenia gravis in black, mixed-ancestry and Caucasian subjects. Heckmann, J.M., Morrison, K.E., Emeryk-Szajewska, B., Strugalska, H., Bergoffen, J., Willcox, N., Newsom-Davis, J. J. Autoimmun. (1996) [Pubmed]
  2. Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis. Garchon, H.J., Djabiri, F., Viard, J.P., Gajdos, P., Bach, J.F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Increased neuromuscular activity causes axonal defects and muscular degeneration. Lefebvre, J.L., Ono, F., Puglielli, C., Seidner, G., Franzini-Armstrong, C., Brehm, P., Granato, M. Development (2004) [Pubmed]
  4. Chromosomal localization of the mouse titin gene and its relation to "muscular dystrophy with myositis" and nebulin genes on chromosome 2. Müller-Seitz, M., Kaupmann, K., Labeit, S., Jockusch, H. Genomics (1993) [Pubmed]
  5. Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man. Garchon, H.J. J. Autoimmun. (2003) [Pubmed]
  6. A dinucleotide repeat and a Hae III polymorphism in the human nicotinic acetylcholine receptor alpha-subunit gene (CHRNA1). Djabiri, F., Gomez, L., Bach, J.F., Garchon, H.J. Clin. Genet. (1997) [Pubmed]
  7. Association of the AChRalpha-subunit gene (CHRNA), DQA1*0101, and the DR3 haplotype in myasthenia gravis. Evidence for a three-gene disease model in a subgroup of patients. Djabiri, F., Caillat-Zucman, S., Gajdos, P., Jaïs, J.P., Gomez, L., Khalil, I., Charron, D., Bach, J.F., Garchon, H.J. J. Autoimmun. (1997) [Pubmed]
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