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Gene Review

pcaD  -  beta-ketoadipate enol-lactone hydrolase

Agrobacterium fabrum str. C58

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High impact information on pcaD

  • Analysis of expression from a pcaD::lacZ promoter probe plasmid revealed that PcaQ and the coinducer exert their effect on a 133-nucleotide region upstream of pcaD [1].
  • A previous study found that the pcaD gene is controlled by an adjacent regulatory gene, pcaQ, which encodes an activator [2].
  • Approximately 4 kb from the pcaD gene are the pcaIJ genes, which encode beta-ketoadipate succinyl-coenzyme A transferase for the next-to-last step of the pathway [2].
  • The activator responded to beta-carboxy-cis,cis-muconate and was shown to control the synthesis of at least three genes (pcaD and pcaHG) [2].


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