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Gene Review:

pcaD - beta-ketoadipate enol-lactone hydrolase

Agrobacterium fabrum str. C58

Parke, D., Parke, D.

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High impact information on pcaD

Analysis of expression from a pcaD::lacZ promoter probe plasmid revealed that PcaQ and the coinducer exert their effect on a 133-nucleotide region upstream of pcaD [1].
A previous study found that the pcaD gene is controlled by an adjacent regulatory gene, pcaQ, which encodes an activator [2].
Approximately 4 kb from the pcaD gene are the pcaIJ genes, which encode beta-ketoadipate succinyl-coenzyme A transferase for the next-to-last step of the pathway [2].
The activator responded to beta-carboxy-cis,cis-muconate and was shown to control the synthesis of at least three genes (pcaD and pcaHG) [2].

References

Characterization of PcaQ, a LysR-type transcriptional activator required for catabolism of phenolic compounds, from Agrobacterium tumefaciens. Parke, D. J. Bacteriol. (1996) [Pubmed]
Supraoperonic clustering of pca genes for catabolism of the phenolic compound protocatechuate in Agrobacterium tumefaciens. Parke, D. J. Bacteriol. (1995) [Pubmed]

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