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Chemical Compound Review

succinyl-CoA     3-[2-[3-[[(2R)-4- [[[(2R,3S,4R,5R)-5-(6...

Synonyms: CHEBI:15380, AC1L3NHJ, C00091, 604-98-8, SCA, ...
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Disease relevance of Succinyl-coenzyme A


High impact information on Succinyl-coenzyme A


Biological context of Succinyl-coenzyme A


Anatomical context of Succinyl-coenzyme A


Associations of Succinyl-coenzyme A with other chemical compounds


Gene context of Succinyl-coenzyme A

  • Succinyl coenzyme A synthetase and Ndk form a complex in P. aeruginosa [16].
  • Methylmalonyl-coenzyme A mutase (MCM) is a 5'-deoxyadenosylcobalamin-linked mitochondrial enzyme that catalyzes the isomerization of L-methylmalonyl-coenzyme A to succinyl-coenzyme A [17].
  • (Ebert, P.S., Tschudy, D.P., Choudhry, J.N. and Chirigos, M.A. (1970) Biochim. Biophys. Acta 208, 236--250) can yield erroneous results with succinyl-coenzyme A as substrate, especially when incubations are carried out for less than 25 min [18].
  • The conversion of succinyl-coenzyme A (CoA) into methylmalonyl-CoA, catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase (MCM), represents an important source of building blocks for rifamycin SV biosynthesis [19].


  1. Capacity for alternating sites cooperativity in catalysis by succinyl-coenzyme A synthetase. Wolodko, W.T., O'Connor, M.D., Bridger, W.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  2. Characterization of the genes encoding beta-ketoadipate: succinyl-coenzyme A transferase in Pseudomonas putida. Parales, R.E., Harwood, C.S. J. Bacteriol. (1992) [Pubmed]
  3. Regulation of citrate synthase from blue-green bacteria by succinyl coenzyme A. Lucas, C., Weitzman, P.D. Arch. Microbiol. (1977) [Pubmed]
  4. The mechansim of action of coenzyme B12. The role thioester in a nonenzyme model reaction for coenzyme B12 Dependent isomerization of methylmalony coenzyme A to succinyl coenzyme A. Scott, A.I., Kang, K. J. Am. Chem. Soc. (1977) [Pubmed]
  5. Global analysis of proteins synthesized by Mycobacterium smegmatis provides direct evidence for physiological heterogeneity in stationary-phase cultures. Blokpoel, M.C., Smeulders, M.J., Hubbard, J.A., Keer, J., Williams, H.D. J. Bacteriol. (2005) [Pubmed]
  6. Succinyl coenzyme A synthetase of Pseudomonas aeruginosa with a broad specificity for nucleoside triphosphate (NTP) synthesis modulates specificity for NTP synthesis by the 12-kilodalton form of nucleoside diphosphate kinase. Kapatral, V., Bina, X., Chakrabarty, A.M. J. Bacteriol. (2000) [Pubmed]
  7. Metabolic pathways for cytotoxic end product formation from glutamate- and aspartate-containing peptides by Porphyromonas gingivalis. Takahashi, N., Sato, T., Yamada, T. J. Bacteriol. (2000) [Pubmed]
  8. Aerobic regulation of the sucABCD genes of Escherichia coli, which encode alpha-ketoglutarate dehydrogenase and succinyl coenzyme A synthetase: roles of ArcA, Fnr, and the upstream sdhCDAB promoter. Park, S.J., Chao, G., Gunsalus, R.P. J. Bacteriol. (1997) [Pubmed]
  9. Localization of the gene (OGDH) coding for the E1k component of the alpha-ketoglutarate dehydrogenase complex to chromosome 7p13-p11.2. Szabo, P., Cai, X., Ali, G., Blass, J.P. Genomics (1994) [Pubmed]
  10. Molecular characterization of the alpha-subunit of Trichomonas vaginalis hydrogenosomal succinyl CoA synthetase. Lahti, C.J., Bradley, P.J., Johnson, P.J. Mol. Biochem. Parasitol. (1994) [Pubmed]
  11. Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. Flippo, T.S., Holder, W.D. Archives of surgery (Chicago, Ill. : 1960) (1993) [Pubmed]
  12. A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency. Odièvre, M.H., Chretien, D., Munnich, A., Robinson, B.H., Dumoulin, R., Masmoudi, S., Kadhom, N., Rötig, A., Rustin, P., Bonnefont, J.P. Hum. Mutat. (2005) [Pubmed]
  13. Ketone-body metabolism in hyperthyroid rats: reduced activity of D-3-hydroxybutyrate dehydrogenase in both liver and heart and of succinyl-coenzyme A: 3-oxoacid coenzyme A-transferase in heart. Lippolis, R., Altamura, N., Landriscina, C. Arch. Biochem. Biophys. (1988) [Pubmed]
  14. Congenital methylmalonic acidemia: a variant of the B12 'non-responsive' form with evidence for reduced affinity of methylmalonyl-CoA mutase for its B12-coenzyme. Baumgartner, E.R., Bachmann, C., Wick, H. Enzyme (1976) [Pubmed]
  15. Modulation of B12 dosage and response in fetal treatment of methylmalonic aciduria (MMA): titration of treatment dose to serum and urine MMA. Evans, M.I., Duquette, D.A., Rinaldo, P., Bawle, E., Rosenblatt, D.S., Whitty, J., Quintero, R.A., Johnson, M.P. Fetal. Diagn. Ther. (1997) [Pubmed]
  16. Regulation of nucleoside diphosphate kinase and secretable virulence factors in Pseudomonas aeruginosa: roles of algR2 and algH. Schlictman, D., Kubo, M., Shankar, S., Chakrabarty, A.M. J. Bacteriol. (1995) [Pubmed]
  17. Comparison of two methods for the measurement of rat liver methylmalonyl-coenzyme A mutase activity: HPLC and radioisotopic assays. Gaire, D., Sponne, I., Droesch, S., Charlier, A., Nicolas, J.P., Lambert, D. J. Nutr. Biochem. (1999) [Pubmed]
  18. Enzymatic degradation of succinyl-coenzyme A by rat liver homogenates. Minaga, T., Sharma, M.L., Kun, E., Piper, W.N. Biochim. Biophys. Acta (1978) [Pubmed]
  19. Molecular analysis and heterologous expression of the gene encoding methylmalonyl-coenzyme A mutase from rifamycin SV-producing strain Amycolatopsis mediterranei U32. Zhang, W., Yang, L., Jiang, W., Zhao, G., Yang, Y., Chiao, J. Appl. Biochem. Biotechnol. (1999) [Pubmed]
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