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Gene Review:

pcaQ - LysR family transcriptional regulator

Agrobacterium fabrum str. C58

Parke, D., Parke, D., Parke, D.

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Disease relevance of pcaQ

Positive regulation of phenolic catabolism in Agrobacterium tumefaciens by the pcaQ gene in response to beta-carboxy-cis,cis-muconate [1].

High impact information on pcaQ

The activator encoded by pcaQ was novel in having the metabolite beta-carboxy-cis,cis-muconate as a coinducer [2].
This communication reports the nucleotide sequence of pcaQ and identifies its deduced polypeptide product as a member of the LysR family of regulatory molecules [2].
The pcaQ gene is upstream of this operon [2].
Previous work demonstrated that catabolism of the phenolic compounds p-hydroxybenzoate and protocatechuate via the beta-ketoadipate pathway in Agrobacterium tumefaciens is mediated by a regulatory gene, pcaQ, that acts in trans to elicit expression of many of the enzymes encoded by the pca genes [2].
A previous study found that the pcaD gene is controlled by an adjacent regulatory gene, pcaQ, which encodes an activator [3].

References

Positive regulation of phenolic catabolism in Agrobacterium tumefaciens by the pcaQ gene in response to beta-carboxy-cis,cis-muconate. Parke, D. J. Bacteriol. (1993) [Pubmed]
Characterization of PcaQ, a LysR-type transcriptional activator required for catabolism of phenolic compounds, from Agrobacterium tumefaciens. Parke, D. J. Bacteriol. (1996) [Pubmed]
Supraoperonic clustering of pca genes for catabolism of the phenolic compound protocatechuate in Agrobacterium tumefaciens. Parke, D. J. Bacteriol. (1995) [Pubmed]

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