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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PIK3IP1  -  phosphoinositide-3-kinase interacting...

Homo sapiens

Synonyms: HGFL, Kringle domain-containing protein HGFL, MGC17330, Phosphoinositide-3-kinase-interacting protein 1, hHGFL(S)
 
 
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High impact information on PIK3IP1

  • In an attempt to understand the molecular mechanism regulating the expression of the gene coding for human hepatocyte growth factor-like protein/macrophage stimulating protein (HGFL), our laboratory has isolated and characterized approximately 4200 bp of the 5'-flanking region of the HGFL gene [1].
  • To determine the location of sites which may be critical for the function of the HGFL gene promoter, we constructed a series of hybrid genes containing serial deletions of this region attached to the coding sequences for chloramphenicol acetyltransferase [1].
  • These results suggest that HGFL gene expression requires CBP, and competition for limiting amounts of CBP by retinoic acid receptor may be a means of modifying the activity of HNF-4 at the HGFL gene promoter [2].
  • In an effort to understand the molecular mechanisms involved in the regulation of expression of the gene encoding hepatocyte growth factor-like protein (HGFL), it was found that all-trans-retinoic acid dramatically represses expression of the endogenous HGFL gene in HepG2 cells, a human hepatocyte-derived cell line [2].
  • Overexpression of CBP also protects the endogenous HGFL gene from down-regulation by retinoic acid [2].
 

Other interactions of PIK3IP1

  • This repression requires the sequence between nucleotides -135 and -105 in the 5'-flanking sequence of the HGFL gene, a site that has previously been shown to bind the transcription factor hepatocyte nuclear factor-4 (HNF-4) [2].

References

  1. Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein. Waltz, S.E., Gould, F.K., Air, E.L., McDowell, S.A., Degen, S.J. J. Biol. Chem. (1996) [Pubmed]
  2. Expression of hepatocyte growth factor-like protein is repressed by retinoic acid and enhanced by cyclic adenosine 3',5'-monophosphate response element-binding protein (CREB)-binding protein (CBP). Muraoka, R.S., Waltz, S.E., Degen, S.J. Endocrinology (1999) [Pubmed]
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