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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Flt4  -  fms-related tyrosine kinase 4

Rattus norvegicus

Synonyms: FLT-4, Flt-4, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, VEGFR-3, ...
 
 
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High impact information on Flt4

  • Flt4 transcripts were found at day 12.5 post-coïtum and thereafter, including the adult mouse, predominantly in the pericardium, pleural membranes and in the lung [1].
  • Flk-1, PDGF-R beta, and FGF-R4 proteins were expressed comparably, however, Flt-4 was not detected [2].
  • The DiI-ac-LDL-labeled free and lymphatic endothelial cells showed immunoreactivity for CD 34 and Flt-4, but most of them did not express either OX 62 or ED 1 immunoreactivity, with only some showing ED 1 immunoreactivity [3].
 

Analytical, diagnostic and therapeutic context of Flt4

References

  1. Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase. Borg, J.P., deLapeyrière, O., Noguchi, T., Rottapel, R., Dubreuil, P., Birnbaum, D. Oncogene (1995) [Pubmed]
  2. Receptor protein tyrosine kinases in perinatal developing rat kidney. Kee, N., McTavish, A.J., Papillon, J., Cybulsky, A.V. Kidney Int. (1997) [Pubmed]
  3. Postnatal development of lymphatic vessels and their smooth muscle cells in the rat diaphragm: a confocal microscopic study. Ohtani, Y., Ohtani, O. Arch. Histol. Cytol. (2001) [Pubmed]
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