Gene Review:
Kdr - kinase insert domain receptor
Rattus norvegicus
Synonyms:
FLK-1, Fetal liver kinase 1, Flk1, Protein-tyrosine kinase receptor flk-1, VEGFR-2, ...
Tufro,
Norwood,
Carey,
Gomez,
Thuringer,
Maulon,
Frelin,
Shihab,
Bennett,
Yi,
Andoh,
Fehrenbach,
Haase,
Kasper,
Koslowski,
Schuh,
Müller,
Fernandez,
Mejias,
Angermayr,
Garcia-Pagan,
Rodés,
Bosch,
Takahashi,
Seko,
Noiri,
Tobe,
Kadowaki,
Sabe,
Yazaki,
Shihab,
Bennett,
Isaac,
Yi,
Andoh,
Sköld,
von Gertten,
Sandberg-Nordqvist,
Mathiesen,
Holmin,
Goldbrunner,
Bendszus,
Wood,
Kiderlen,
Sasaki,
Tonn,
Byzova,
Goldman,
Jankau,
Chen,
Cabrera,
Achen,
Stacker,
Carnevale,
Siemionow,
Deitcher,
DiCorleto,
Tufro-McReddie,
Norwood,
Aylor,
Botkin,
Carey,
Gomez,
- Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression. Kanellis, J., Paizis, K., Cox, A.J., Stacker, S.A., Gilbert, R.E., Cooper, M.E., Power, D.A. Kidney Int. (2002)
- Vascular endothelial growth factor and its receptors in control and diabetic rat eyes. Gilbert, R.E., Vranes, D., Berka, J.L., Kelly, D.J., Cox, A., Wu, L.L., Stacker, S.A., Cooper, M.E. Lab. Invest. (1998)
- Vascular endothelial growth factor mediates vasogenic edema in acute lead encephalopathy. Hossain, M.A., Russell, J.C., Miknyoczki, S., Ruggeri, B., Lal, B., Laterra, J. Ann. Neurol. (2004)
- Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. Plate, K.H., Beck, H., Danner, S., Allegrini, P.R., Wiessner, C. J. Neuropathol. Exp. Neurol. (1999)
- Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Byzova, T.V., Goldman, C.K., Jankau, J., Chen, J., Cabrera, G., Achen, M.G., Stacker, S.A., Carnevale, K.A., Siemionow, M., Deitcher, S.R., DiCorleto, P.E. Blood (2002)
- Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes. Takahashi, N., Seko, Y., Noiri, E., Tobe, K., Kadowaki, T., Sabe, H., Yazaki, Y. Circ. Res. (1999)
- Vascular endothelial growth factor increases the mitogenic response to fibroblast growth factor-2 in vascular smooth muscle cells in vivo via expression of fms-like tyrosine kinase-1. Couper, L.L., Bryant, S.R., Eldrup-Jørgensen, J., Bredenberg, C.E., Lindner, V. Circ. Res. (1997)
- Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. Schänzer, A., Wachs, F.P., Wilhelm, D., Acker, T., Cooper-Kuhn, C., Beck, H., Winkler, J., Aigner, L., Plate, K.H., Kuhn, H.G. Brain Pathol. (2004)
- Alterations in the immunohistochemical distribution patterns of vascular endothelial growth factor receptors Flk1 and Flt1 in bleomycin-induced rat lung fibrosis. Fehrenbach, H., Haase, M., Kasper, M., Koslowski, R., Schuh, D., Müller, M. Virchows Arch. (1999)
- PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Goldbrunner, R.H., Bendszus, M., Wood, J., Kiderlen, M., Sasaki, M., Tonn, J.C. Neurosurgery (2004)
- Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1. Fukuda, S., Kaga, S., Zhan, L., Bagchi, D., Das, D.K., Bertelli, A., Maulik, N. Cell Biochem. Biophys. (2006)
- Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival. Takamoto, T., Sasaki, M., Kuno, T., Tamaki, N. The Kobe journal of medical sciences. (2001)
- Nitric oxide modulates vascular endothelial growth factor and receptors in chronic cyclosporine nephrotoxicity. Shihab, F.S., Bennett, W.M., Isaac, J., Yi, H., Andoh, T.F. Kidney Int. (2003)
- Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition. Gavin, T.P., Wagner, P.D. Acta Physiol. Scand. (2002)
- Rapid transactivation of the vascular endothelial growth factor receptor KDR/Flk-1 by the bradykinin B2 receptor contributes to endothelial nitric-oxide synthase activation in cardiac capillary endothelial cells. Thuringer, D., Maulon, L., Frelin, C. J. Biol. Chem. (2002)
- Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia. Shiote, M., Nagano, I., Ilieva, H., Murakami, T., Narai, H., Ohta, Y., Nagata, T., Shoji, M., Abe, K. Neuroscience (2005)
- Nitric oxide, VEGF, and VEGFR-2: interactions in activity-induced angiogenesis in rat skeletal muscle. Milkiewicz, M., Hudlicka, O., Brown, M.D., Silgram, H. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Oxygen regulates vascular endothelial growth factor-mediated vasculogenesis and tubulogenesis. Tufro-McReddie, A., Norwood, V.F., Aylor, K.W., Botkin, S.J., Carey, R.M., Gomez, R.A. Dev. Biol. (1997)
- Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats. Fernandez, M., Mejias, M., Angermayr, B., Garcia-Pagan, J.C., Rodés, J., Bosch, J. J. Hepatol. (2005)
- Expression of vascular endothelial growth factor and its receptors Flt-1 and KDR/Flk-1 in chronic cyclosporine nephrotoxicity. Shihab, F.S., Bennett, W.M., Yi, H., Andoh, T.F. Transplantation (2001)
- A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: implication in tumor angiogenesis. Lamy, S., Ruiz, M.T., Wisniewski, J., Garde, S., Rabbani, S.A., Panchal, C., Wu, J.J., Annabi, B. Int. J. Cancer (2006)
- Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Kirkin, V., Mazitschek, R., Krishnan, J., Steffen, A., Waltenberger, J., Pepper, M.S., Giannis, A., Sleeman, J.P. Eur. J. Biochem. (2001)
- Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. Wick, A., Wick, W., Waltenberger, J., Weller, M., Dichgans, J., Schulz, J.B. J. Neurosci. (2002)
- VEGF and VEGF receptor expression after experimental brain contusion in rat. Sköld, M.K., von Gertten, C., Sandberg-Nordqvist, A.C., Mathiesen, T., Holmin, S. J. Neurotrauma (2005)
- Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Zheng, W., Christensen, L.P., Tomanek, R.J. Am. J. Physiol. Heart Circ. Physiol. (2004)
- Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors. Arsic, N., Zentilin, L., Zacchigna, S., Santoro, D., Stanta, G., Salvi, A., Sinagra, G., Giacca, M. Mol. Ther. (2003)
- Immunohistochemical analysis of vascular endothelial growth factor and hepatocyte growth factor, and their receptors, in transplanted islets in rats. Watanabe, H., Sumi, S., Kitamura, Y., Nio, Y., Higami, T. Surgery today. (2003)
- Aging and orchidectomy modulate expression of VEGF receptors (Flt-1 and Flk-1) on corpus cavernosum of the rat. Neves, D., Santos, J., Tomada, N., Almeida, H., Vendeira, P. Ann. N. Y. Acad. Sci. (2006)
- Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair. Colwell, A.S., Beanes, S.R., Soo, C., Dang, C., Ting, K., Longaker, M.T., Atkinson, J.B., Lorenz, H.P. Plast. Reconstr. Surg. (2005)
- Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. Tufro, A., Norwood, V.F., Carey, R.M., Gomez, R.A. J. Am. Soc. Nephrol. (1999)