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Gene Review

Pdgfrb  -  platelet derived growth factor receptor,...

Rattus norvegicus

Synonyms: Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, PDGF-R-beta, PDGFR-1, ...
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Disease relevance of Pdgfrb


High impact information on Pdgfrb


Biological context of Pdgfrb


Anatomical context of Pdgfrb


Associations of Pdgfrb with chemical compounds

  • In the presence of intact promoter-binding by Myc, trichostatin A (TSA) can block Myc repression of PDGFRB in vivo, again demonstrating that promoter-binding and repression are separable [7].

Physical interactions of Pdgfrb


Other interactions of Pdgfrb

  • A progressive increase with age in aortic steady-state messenger RNA (mRNA) levels of the receptor for the B chain of PDGF (PDGF-r beta) was present in all three strains but was greatest in the SHR [1].
  • In summary, our results indicate that neointimal cells are more sensitive to growth factors than medial cells, likely due to a higher expression of IGF-I receptor and PDGF-R beta [9].
  • IGF-I receptor and PDGF-R beta levels were higher in neointimal cells than in medial cells, but the FGF receptor level was not different between the cell types [9].
  • Promoter-binding and repression of PDGFRB by c-Myc are separable activities [7].


  1. Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart. Sarzani, R., Arnaldi, G., Takasaki, I., Brecher, P., Chobanian, A.V. Hypertension (1991) [Pubmed]
  2. Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat. Iida, H., Seifert, R., Alpers, C.E., Gronwald, R.G., Phillips, P.E., Pritzl, P., Gordon, K., Gown, A.M., Ross, R., Bowen-Pope, D.F. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. Increased binding and chemotactic capacities of PDGF-BB on fibroblasts in radiation pneumonitis. Tada, H., Ogushi, F., Tani, K., Nishioka, Y., Miyata, J.Y., Sato, K., Asano, T., Sone, S. Radiat. Res. (2003) [Pubmed]
  4. Chrysotile asbestos upregulates gene expression and production of alpha-receptors for platelet-derived growth factor (PDGF-AA) on rat lung fibroblasts. Bonner, J.C., Goodell, A.L., Coin, P.G., Brody, A.R. J. Clin. Invest. (1993) [Pubmed]
  5. Expression and localization of platelet-derived growth factor ligand and receptor protein during acute and chronic rejection of rat cardiac allografts. Lemström, K.B., Koskinen, P.K. Circulation (1997) [Pubmed]
  6. Receptor protein tyrosine kinases in perinatal developing rat kidney. Kee, N., McTavish, A.J., Papillon, J., Cybulsky, A.V. Kidney Int. (1997) [Pubmed]
  7. Promoter-binding and repression of PDGFRB by c-Myc are separable activities. Mao, D.Y., Barsyte-Lovejoy, D., Ho, C.S., Watson, J.D., Stojanova, A., Penn, L.Z. Nucleic Acids Res. (2004) [Pubmed]
  8. Platelet-derived growth factor (PDGF)-AA, -AB, and -BB induce differential chemotaxis of early-passage rat lung fibroblasts in vitro. Osornio-Vargas, A.R., Goodell, A.L., Hernández-Rodríguez, N.A., Brody, A.R., Coin, P.G., Badgett, A., Bonner, J.C. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  9. Different growth properties of neointimal and medial smooth muscle cells in response to growth factors. Myit, S., Delafontaine, P., Bochaton-Piallat, M.L., Giraud, S., Gabbiani, G., Brink, M. J. Vasc. Res. (2003) [Pubmed]
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