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CHRNB3  -  cholinergic receptor, nicotinic, beta 3...

Homo sapiens

Synonyms: Neuronal acetylcholine receptor subunit beta-3
 
 
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High impact information on CHRNB3

  • The area where the LOD score reaches the maximum encompasses the location of the gene for the beta3-subunit of the nicotinic acetylcholine receptor (CHRNB3), thus making this gene a possible candidate for these specific forms of adolescent-onset IGE [1].
 

Biological context of CHRNB3

 

Other interactions of CHRNB3

  • The strongest association was from an SNP representing CHRNB3, the beta3 nicotinic receptor subunit gene (P = 9.4 x 10(-5)) [3].

References

  1. Evidence for linkage of adolescent-onset idiopathic generalized epilepsies to chromosome 8-and genetic heterogeneity. Durner, M., Zhou, G., Fu, D., Abreu, P., Shinnar, S., Resor, S.R., Moshe, S.L., Rosenbaum, D., Cohen, J., Harden, C., Kang, H., Wallace, S., Luciano, D., Ballaban-Gil, K., Klotz, I., Dicker, E., Greenberg, D.A. Am. J. Hum. Genet. (1999) [Pubmed]
  2. Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2. Koyama, K., Sudo, K., Nakamura, Y. Genomics (1994) [Pubmed]
  3. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Saccone, S.F., Hinrichs, A.L., Saccone, N.L., Chase, G.A., Konvicka, K., Madden, P.A., Breslau, N., Johnson, E.O., Hatsukami, D., Pomerleau, O., Swan, G.E., Goate, A.M., Rutter, J., Bertelsen, S., Fox, L., Fugman, D., Martin, N.G., Montgomery, G.W., Wang, J.C., Ballinger, D.G., Rice, J.P., Bierut, L.J. Hum. Mol. Genet. (2007) [Pubmed]
 
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