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Gene Review:

irp2 - HMWP2 nonribosomal peptide synthetase

Yersinia pestis KIM10+

Bultreys, A. et al., Iteman, I. et al., Fetherston, J.D. et al., Fetherston, J.D. et al., Bearden, S.W. et al., et al.

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Disease relevance of irp2

HPLC-proven yersiniabactin-producing E. coli lacked modifications found in irp1 and irp2 in the human pathogen CFT073, and it is not clear whether CFT073 produces yersiniabactin [1].
Relationship between loss of pigmentation and deletion of the chromosomal iron-regulated irp2 gene in Yersinia pestis: evidence for separate but related events [2].

High impact information on irp2

Sequence analysis of the region upstream of irp2 revealed the presence of a gene (ybtA) with homology to the AraC family of transcriptional regulators [3].
Finally, Y. pestis strains with mutations in either the psn or irp2 gene were avirulent in mice when inoculated subcutaneously [4].
The irp2 gene, coding for a 190-kDa iron-regulated protein (HMWP2), and the hemin storage locus (hms), which determines Yersinia pestis pigmentation, are each located on a large chromosomal fragment which carries virulence genes and deletes spontaneously [2].
Virulence-associated fyuA/irp2 gene cluster of Yersinia enterocolitica biotype 1B carries a novel insertion sequence IS1328 [5].

Regulatory relationships of irp2

In addition, this strain as well as a Y. pestis strain with a mutation constructed in the gene (irp2) encoding the 190-kDa iron-regulated protein HMWP2 could not grow at 37 degrees C in a defined, iron-deficient medium [6].

References

Yersiniabactin production by Pseudomonas syringae and Escherichia coli, and description of a second yersiniabactin locus evolutionary group. Bultreys, A., Gheysen, I., de Hoffmann, E. Appl. Environ. Microbiol. (2006) [Pubmed]
Relationship between loss of pigmentation and deletion of the chromosomal iron-regulated irp2 gene in Yersinia pestis: evidence for separate but related events. Iteman, I., Guiyoule, A., de Almeida, A.M., Guilvout, I., Baranton, G., Carniel, E. Infect. Immun. (1993) [Pubmed]
YbtA, an AraC-type regulator of the Yersinia pestis pesticin/yersiniabactin receptor. Fetherston, J.D., Bearden, S.W., Perry, R.D. Mol. Microbiol. (1996) [Pubmed]
Genetic organization of the yersiniabactin biosynthetic region and construction of avirulent mutants in Yersinia pestis. Bearden, S.W., Fetherston, J.D., Perry, R.D. Infect. Immun. (1997) [Pubmed]
Virulence-associated fyuA/irp2 gene cluster of Yersinia enterocolitica biotype 1B carries a novel insertion sequence IS1328. Rakin, A., Heesemann, J. FEMS Microbiol. Lett. (1995) [Pubmed]
Analysis of the pesticin receptor from Yersinia pestis: role in iron-deficient growth and possible regulation by its siderophore. Fetherston, J.D., Lillard, J.W., Perry, R.D. J. Bacteriol. (1995) [Pubmed]

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