Gene Review:
HMWP2 - nonribosomal peptide synthetase
Yersinia pestis KIM10+
- The pigmentation locus of Yersinia pestis KIM6+ is flanked by an insertion sequence and includes the structural genes for pesticin sensitivity and HMWP2. Fetherston, J.D., Perry, R.D. Mol. Microbiol. (1994)
- Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: interaction of the 1-1382 and 1383-2035 fragments. Suo, Z., Walsh, C.T., Miller, D.A. Biochemistry (1999)
- Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase. Suo, Z., Tseng, C.C., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis. Miller, D.A., Luo, L., Hillson, N., Keating, T.A., Walsh, C.T. Chem. Biol. (2002)
- Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis. Gehring, A.M., DeMoll, E., Fetherston, J.D., Mori, I., Mayhew, G.F., Blattner, F.R., Walsh, C.T., Perry, R.D. Chem. Biol. (1998)
- Yersiniabactin production requires the thioesterase domain of HMWP2 and YbtD, a putative phosphopantetheinylate transferase. Bobrov, A.G., Geoffroy, V.A., Perry, R.D. Infect. Immun. (2002)
- Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase. Keating, T.A., Miller, D.A., Walsh, C.T. Biochemistry (2000)
- Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holo-carrier protein domain. Keating, T.A., Suo, Z., Ehmann, D.E., Walsh, C.T. Biochemistry (2000)
- The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis. Gehring, A.M., Mori, I., Perry, R.D., Walsh, C.T. Biochemistry (1998)
- Analysis of the pesticin receptor from Yersinia pestis: role in iron-deficient growth and possible regulation by its siderophore. Fetherston, J.D., Lillard, J.W., Perry, R.D. J. Bacteriol. (1995)
- Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation. Perry, R.D., Balbo, P.B., Jones, H.A., Fetherston, J.D., DeMoll, E. Microbiology (Reading, Engl.) (1999)
- Relationship between loss of pigmentation and deletion of the chromosomal iron-regulated irp2 gene in Yersinia pestis: evidence for separate but related events. Iteman, I., Guiyoule, A., de Almeida, A.M., Guilvout, I., Baranton, G., Carniel, E. Infect. Immun. (1993)