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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

y3304  -  hypothetical protein

Yersinia pestis KIM10+

 
 
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Disease relevance of y3304

  • ATP-dependent secretion was particularly sensitive to changes in cortical actin stability and was inhibited by expression of a protein (Yersinia pestis protein kinase A) that disassembles cortical f-actin and by pharmacological agents that promote either disassembly or stabilization of actin [1].
 

High impact information on y3304

  • This process involves the YopE protein, which induces disruption of the host cell actin microfilament structure [2].
  • It has long been believed that the cortical actin cytoskeleton plays an important role in regulating the secretion of hormones and neurotransmitters [1].
  • Manipulations that decreased levels of phosphatidylinositol-4,5-bisphosphate (PIP(2)) (e.g., removal of ATP, the expression of a protein that can sequester PIP(2)) rapidly reduced the amount of cortical actin [1].
 

Analytical, diagnostic and therapeutic context of y3304

References

  1. Phosphatidylinositol-4,5-bisphosphate: actin dynamics and the regulation of ATP-dependent and -independent secretion. Bittner, M.A., Holz, R.W. Mol. Pharmacol. (2005) [Pubmed]
  2. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. Rosqvist, R., Magnusson, K.E., Wolf-Watz, H. EMBO J. (1994) [Pubmed]
  3. Recombinant Yersinia YopT leads to uncoupling of RhoA-effector interaction. Sorg, I., Goehring, U.M., Aktories, K., Schmidt, G. Infect. Immun. (2001) [Pubmed]
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