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Gene Review:

Scpep1 - serine carboxypeptidase 1

Rattus norvegicus

Synonyms: Retinoid-inducible serine carboxypeptidase, Risc, Serine carboxypeptidase 1

Ostrowska, H. et al., Hamazaki, H.

Ostrowska, Kalinowska, Chabielska, Stankiewicz, Kruszewski, Buczko,

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High impact information on Scpep1

The carboxypeptidase activity in the brain was completely inhibited by 1 mM phenylmethylsulfonyl fluoride, suggesting the protease is a serine carboxypeptidase [1].
The injection of ebelactone B did not affect the mean blood pressure of 2K1C hypertensive rats but lowered an elevated extracellular serine carboxypeptidase cathepsin A-like activity [2].
The present study was undertaken to investigate whether ebelactone B, an inhibitor of bradykinin and angiotensin I hydrolysis by serine carboxypeptidase Y-like enzymes, could influence platelet aggregation ex vivo in renovascular hypertensive rats (2-kidney, 1-clip Goldblatt model, 2K1C) [2].

References

Carboxy-terminal truncation of long-tailed amyloid beta-peptide is inhibited by serine protease inhibitor and peptide aldehyde. Hamazaki, H. FEBS Lett. (1998) [Pubmed]
Ebelactone B, an inhibitor of extracellular cathepsin A-type enzyme, suppresses platelet aggregation ex vivo in renovascular hypertensive rats. Ostrowska, H., Kalinowska, J., Chabielska, E., Stankiewicz, A., Kruszewski, K., Buczko, W. J. Cardiovasc. Pharmacol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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