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Gene Review

Adam15  -  a disintegrin and metallopeptidase domain...

Mus musculus

Synonyms: AD56, ADAM 15, Disintegrin and metalloproteinase domain-containing protein 15, MDC-15, MDC15, ...
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High impact information on Adam15

  • Metargidin, a transmembrane protein of the adamalysin family, and integrins, e.g., alpha5beta1 and alphav, are preferentially expressed on endothelial cells on angiogenesis [1].
  • Adam9, Adam15 and Adam21, genes encoding members of the ADAM or MDC family of metalloproteases, have been mapped to mouse chromosomes 8, 1, and 12, respectively, using an interspecific cross [2].


  1. Evidence of antiangiogenic and antimetastatic activities of the recombinant disintegrin domain of metargidin. Trochon-Joseph, V., Martel-Renoir, D., Mir, L.M., Thomaïdis, A., Opolon, P., Connault, E., Li, H., Grenet, C., Fauvel-Lafève, F., Soria, J., Legrand, C., Soria, C., Perricaudet, M., Lu, H. Cancer Res. (2004) [Pubmed]
  2. Chromosomal mapping of Adam9, Adam15 and Adam21. Seldin, M.F., Hirohata, S., Apte, S.S. Matrix Biol. (2000) [Pubmed]
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