Gene Review:
ADAM15 - ADAM metallopeptidase domain 15
Homo sapiens
Synonyms:
ADAM 15, Disintegrin and metalloproteinase domain-containing protein 15, MDC-15, MDC15, Metalloprotease RGD disintegrin protein, ...
- Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. Schäfer, B., Marg, B., Gschwind, A., Ullrich, A. J. Biol. Chem. (2004)
- Potential role for ADAM15 in pathological neovascularization in mice. Horiuchi, K., Weskamp, G., Lum, L., Hammes, H.P., Cai, H., Brodie, T.A., Ludwig, T., Chiusaroli, R., Baron, R., Preissner, K.T., Manova, K., Blobel, C.P. Mol. Cell. Biol. (2003)
- Aberrant alternative exon use and increased copy number of human metalloprotease-disintegrin ADAM15 gene in breast cancer cells. Ortiz, R.M., Kärkkäinen, I., Huovila, A.P. Genes Chromosomes Cancer (2004)
- ADAM15 decreases integrin alphavbeta3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion. Beck, V., Herold, H., Benge, A., Luber, B., Hutzler, P., Tschesche, H., Kessler, H., Schmitt, M., Geppert, H.G., Reuning, U. Int. J. Biochem. Cell Biol. (2005)
- Expression of ADAM15 in lung carcinomas. Schütz, A., Härtig, W., Wobus, M., Grosche, J., Wittekind, C.h., Aust, G. Virchows Arch. (2005)
- Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. Poghosyan, Z., Robbins, S.M., Houslay, M.D., Webster, A., Murphy, G., Edwards, D.R. J. Biol. Chem. (2002)
- ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin. Ham, C., Levkau, B., Raines, E.W., Herren, B. Exp. Cell Res. (2002)
- Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization. Kärkkäinen, I., Karhu, R., Huovila, A.P. Cytogenet. Cell Genet. (2000)
- Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes. Flannery, C.R., Little, C.B., Caterson, B., Hughes, C.E. Matrix Biol. (1999)
- Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome. Bernstein, H.G., Bukowska, A., Krell, D., Bogerts, B., Ansorge, S., Lendeckel, U. J. Neurocytol. (2003)
- Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. Eto, K., Huet, C., Tarui, T., Kupriyanov, S., Liu, H.Z., Puzon-McLaughlin, W., Zhang, X.P., Sheppard, D., Engvall, E., Takada, Y. J. Biol. Chem. (2002)
- ADAM15 overexpression in NIH3T3 cells enhances cell-cell interactions. Herren, B., Garton, K.J., Coats, S., Bowen-Pope, D.F., Ross, R., Raines, E.W. Exp. Cell Res. (2001)
- Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. Krätzschmar, J., Lum, L., Blobel, C.P. J. Biol. Chem. (1996)
- Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis. Komiya, K., Enomoto, H., Inoki, I., Okazaki, S., Fujita, Y., Ikeda, E., Ohuchi, E., Matsumoto, H., Toyama, Y., Okada, Y. Arthritis Res. Ther. (2005)
- Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy. Fedak, P.W., Moravec, C.S., McCarthy, P.M., Altamentova, S.M., Wong, A.P., Skrtic, M., Verma, S., Weisel, R.D., Li, R.K. Circulation (2006)
- Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion. Iba, K., Albrechtsen, R., Gilpin, B.J., Loechel, F., Wewer, U.M. Am. J. Pathol. (1999)
- Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. Worley, J.R., Baugh, M.D., Hughes, D.A., Edwards, D.R., Hogan, A., Sampson, M.J., Gavrilovic, J. J. Biol. Chem. (2003)
- Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Böhm, B.B., Aigner, T., Roy, B., Brodie, T.A., Blobel, C.P., Burkhardt, H. Arthritis Rheum. (2005)
- ADAM15 upregulation and interaction with multiple binding partners in inflammatory bowel disease. Mosnier, J.F., Jarry, A., Bou-Hanna, C., Denis, M.G., Merlin, D., Laboisse, C.L. Lab. Invest. (2006)