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Gene Review:

Adam15 - ADAM metallopeptidase domain 15

Rattus norvegicus

Synonyms: ADAM 15, CRII-7, Disintegrin and metalloproteinase domain-containing protein 15, MDC-15, MDC15, ...

Bosse, F. et al.

Bosse, Petzold, Greiner-Petter, Pippirs, Gillen, Müller,

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Disease relevance of Adam15

Analysis of the CRII-7/rMDC15 transcript levels following peripheral nerve lesions demonstrated regulated mRNA expression during Wallerian degeneration and nerve regeneration [1].

High impact information on Adam15

We have isolated a 2815-bp rat cDNA (CRII-7) representing a transcript that is differentially expressed during sciatic nerve regeneration [1].
The CRII-7 cDNA (rMDC15) encodes a membrane-anchored glycoprotein of approximately 85 kDa containing a disintegrin and a metalloprotease domain [1].
In situ hybridization on paraffin sections showed the cellular localization of CRII-7/rMDC15 mRNA in Schwann cells and endothelial cells of peripheral nerve and in various neuronal populations in brain and spinal cord [1].
CRII-7/rMDC15 mRNA expression was further examined during postnatal development and maturation of rat sciatic nerve and brain, as well as in cultured Schwann cells, meningeal fibroblasts, and astrocytes [1].

Analytical, diagnostic and therapeutic context of Adam15

Northern blot analysis demonstrated a predominant expression of CRII-7/rMDC15 in the nervous system (PNS and CNS) and lung [1].

References

Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury. Bosse, F., Petzold, G., Greiner-Petter, R., Pippirs, U., Gillen, C., Müller, H.W. Glia (2000) [Pubmed]

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