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Adam21  -  a disintegrin and metallopeptidase domain 21

Mus musculus

Synonyms: ADAM 21, ADAM 31, ADAM31, Adam31, Disintegrin and metalloproteinase domain-containing protein 21, ...
 
 
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High impact information on Adam21

  • ADAM 31 is expressed in Leydig cells of the testes, but unlike many other ADAMs, it is not found on developing sperm [1].
  • Messenger RNA encoding ADAM 31 was most abundant in testes, but was also detected in many other tissues [1].
  • The complementary DNA sequence of ADAM 31 predicts a transmembrane protein with metalloproteinase, disintegrin, cysteine-rich, and cytoplasmic domains [1].
  • Furthermore, ADAM 31 is highly expressed on four types of specialized epithelia: the cauda epididymidis, the vas deferens, the convoluted tubules of the kidney, and the parietal cells of the stomach [1].
  • Chromosomal mapping of Adam9, Adam15 and Adam21 [2].
 

Biological context of Adam21

  • Adam9, Adam15 and Adam21, genes encoding members of the ADAM or MDC family of metalloproteases, have been mapped to mouse chromosomes 8, 1, and 12, respectively, using an interspecific cross [2].
 

Anatomical context of Adam21

References

  1. Identification of ADAM 31: a protein expressed in Leydig cells and specialized epithelia. Liu, L., Smith, J.W. Endocrinology (2000) [Pubmed]
  2. Chromosomal mapping of Adam9, Adam15 and Adam21. Seldin, M.F., Hirohata, S., Apte, S.S. Matrix Biol. (2000) [Pubmed]
 
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