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Gene Review

RMI2  -  RecQ mediated genome instability 2

Homo sapiens

Synonyms: BLAP18, BLM-associated protein of 18 kDa, C16orf75, MGC24665, RecQ-mediated genome instability protein 2, ...

Discovery and nomenclature

The full-length cDNA of C16orf75 was first cloned, sequenced and deposited by the National Institutes of Health Mammalian Gene Collection (MGC) program team (MGC24665) [1]. The gene corresponding to MGC24665 cDNA was named C16orf75 suggesting it is a putative ORF number 75 located on chromosome 16 [2]. The protein encoded by C16orf75 was first identified as a component of the BLM protein complex independently by two different groups [3][4]. The protein was named as BLAP18 (BLM-associated polypeptide of 18 kDa mass) or RMI2 (RecQ-mediated genome instability 2)[3][4].



  • RMI2 is a 147 amino acid protein with a predicted molecular weight of 15.9 kDa [3][4].
  • RMI2 had an apparent molecular mass of 18 to 20 kD by SDS-PAGE [3][4].
  • RMI2 contains a putative OB-fold domain. The OB-fold domain of RMI2 is more similar to the OB-fold domain "D" in RPA2 [3][4].








Secondary modifications

  • RMI2 is phosphorylated during mitosis [3].



  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg, R.L., Feingold, E.A., Grouse, L.H., Derge, J.G., Klausner, R.D., Collins, F.S., Wagner, L., Shenmen, C.M., Schuler, G.D., Altschul, S.F., Zeeberg, B., Buetow, K.H., Schaefer, C.F., Bhat, N.K., Hopkins, R.F., Jordan, H., Moore, T., Max, S.I., Wang, J., Hsieh, F., Diatchenko, L., Marusina, K., Farmer, A.A., Rubin, G.M., Hong, L., Stapleton, M., Soares, M.B., Bonaldo, M.F., Casavant, T.L., Scheetz, T.E., Brownstein, M.J., Usdin, T.B., Toshiyuki, S., Carninci, P., Prange, C., Raha, S.S., Loquellano, N.A., Peters, G.J., Abramson, R.D., Mullahy, S.J., Bosak, S.A., McEwan, P.J., McKernan, K.J., Malek, J.A., Gunaratne, P.H., Richards, S., Worley, K.C., Hale, S., Garcia, A.M., Gay, L.J., Hulyk, S.W., Villalon, D.K., Muzny, D.M., Sodergren, E.J., Lu, X., Gibbs, R.A., Fahey, J., Helton, E., Ketteman, M., Madan, A., Rodrigues, S., Sanchez, A., Whiting, M., Madan, A., Young, A.C., Shevchenko, Y., Bouffard, G.G., Blakesley, R.W., Touchman, J.W., Green, E.D., Dickson, M.C., Rodriguez, A.C., Grimwood, J., Schmutz, J., Myers, R.M., Butterfield, Y.S., Krzywinski, M.I., Skalska, U., Smailus, D.E., Schnerch, A., Schein, J.E., Jones, S.J., Marra, M.A. Proc. Natl. Acad. Sci. U. S. A. (2002) [Pubmed]
  2. Guidelines for human gene nomenclature. Wain, H.M., Bruford, E.A., Lovering, R.C., Lush, M.J., Wright, M.W., Povey, S. Genomics. (2002) [Pubmed]
  3. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Singh, T.R., Ali, A.M., Busygina, V., Raynard, S., Fan, Q., Du, C.H., Andreassen, P.R., Sung, P., Meetei, A.R. Genes. Dev. (2008) [Pubmed]
  4. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Xu, D., Guo, R., Sobeck, A., Bachrati, C.Z., Yang, J., Enomoto, T., Brown, G.W., Hoatlin, M.E., Hickson, I.D., Wang, W. Genes. Dev. (2008) [Pubmed]
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