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Chemical Compound Review

Methylmesilate     methylsulfonyloxymethane

Synonyms: methylmesylate, SPECTRUM330003, CCRIS 396, Methyl mesylate, Mesilate, Methyl, ...
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Psychiatry related information on METHYL METHANESULFONATE


High impact information on METHYL METHANESULFONATE

  • Both subunits are required in vivo for resistance to DNA damage by methylmethane sulfonate (MMS) [6].
  • Consistent with this theory, stationary phase alkB cells were less MMS sensitive than rapidly growing cells [1].
  • The single-strand damage processed by AlkB was primarily cytotoxic and not mutagenic and was induced by SN2 methylating agents, MMS, DMS, and MeI but not by SN1 agent N-methyl-N-nitrosourea or by gamma irradiation [1].
  • Increased sensitivity to genotoxic agents, particularly ultraviolet light and methylmethanesulfonate, shows that Brca2 function is essential for the ability to survive DNA damage [7].
  • 53BP1 foci formation is not restricted to gamma-radiation but is also detected in response to UV radiation as well as hydroxyurea, camptothecin, etoposide, and methylmethanesulfonate treatment [8].

Chemical compound and disease context of METHYL METHANESULFONATE






Associations of METHYL METHANESULFONATE with other chemical compounds

  • Furthermore, the mutation frequency induced by methylmethanesulfonate was reduced to 50% of normal by expression of 3-methyladenine I activity in the Chinese hamster cells, indicating that m3A is not only a cytotoxic but also a premutagenic lesion in mammalian cells [15].
  • Mobility-shift and structural analyses show that the MBD of MBD1 binds a methyl-CpG pair (mCpG x mCpG) but not the methyl-CpG pair containing a single 7-methylguanine (N) (mCpG x mCpN) that is known as one of the major lesions caused by MMS [20].
  • The frequency of mutations formed in the hypoxanthine phosphoribosyl transferase (hprt) locus was investigated after methylmethanesulfonate (MMS), ethylmethanesulfonate (EMS), N-nitroso-N-methylurea (NMU) and N-nitroso-N-ethylurea (NEU) exposure [21].
  • This review focuses on the DNA methyl damage caused by MMS and MNNG for each site of potential methylation to summarize what is known about the repair of such damage and the downstream responses and consequences if the damage is not repaired [22].
  • The protein kinase inhibitor staurosporine and the temperature sensitive (ts) p34cdc2 mutant reduced induction by the alkylating agent methylmethane sulfonate (MMS) of the rodent gadd45 and gadd153 genes [23].


  • We further demonstrate that knockdown of MBD1 by specific small interfering RNAs significantly increases cell sensitivity to MMS [20].
  • A comet assay demonstrated that DNA repair after MMS or UV treatment was impaired in the cells expressing nuclease-deficient FEN-1 but not in the cells with double-mutated FEN-1 [24].
  • Other aspects of the genomic responses were independent of Mec1p, and likely independent of DNA damage, suggesting the pleiotropic effects of MMS and ionizing radiation [25].
  • Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment [26].
  • Deleting the APN1 gene largely restored the resistance of rad27 mutants to MMS [27].

Analytical, diagnostic and therapeutic context of METHYL METHANESULFONATE


  1. Defective processing of methylated single-stranded DNA by E. coli AlkB mutants. Dinglay, S., Trewick, S.C., Lindahl, T., Sedgwick, B. Genes Dev. (2000) [Pubmed]
  2. A new member of the endonuclease III family of DNA repair enzymes that removes methylated purines from DNA. Begley, T.J., Haas, B.J., Noel, J., Shekhtman, A., Williams, W.A., Cunningham, R.P. Curr. Biol. (1999) [Pubmed]
  3. Enhanced capacity of DNA repair in human cytomegalovirus-infected cells. Nishiyama, Y., Rapp, F. J. Virol. (1981) [Pubmed]
  4. Methylmethanesulfonate-induced DNA damage and its repair in cultured human fibroblasts: normal rates of induction and removal of alkali-labile sites in xeroderma pigmentosum (group A) cells. Mirzayans, R., Liuzzi, M., Paterson, M.C. Carcinogenesis (1988) [Pubmed]
  5. DNA repair deficiency for alkylation damage in cells from Alzheimer's disease patients. Bradley, W.G., Polinsky, R.J., Pendlebury, W.W., Jones, S.K., Nee, L.E., Bartlett, J.D., Hartshorn, J.N., Tandan, R., Sweet, L., Magin, G.K. Prog. Clin. Biol. Res. (1989) [Pubmed]
  6. Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Fricke, W.M., Brill, S.J. Genes Dev. (2003) [Pubmed]
  7. Involvement of Brca2 in DNA repair. Patel, K.J., Yu, V.P., Lee, H., Corcoran, A., Thistlethwaite, F.C., Evans, M.J., Colledge, W.H., Friedman, L.S., Ponder, B.A., Venkitaraman, A.R. Mol. Cell (1998) [Pubmed]
  8. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. Rappold, I., Iwabuchi, K., Date, T., Chen, J. J. Cell Biol. (2001) [Pubmed]
  9. Alp, a suppressor of lon protease mutants in Escherichia coli. Trempy, J.E., Gottesman, S. J. Bacteriol. (1989) [Pubmed]
  10. Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. Grishin, A.V., Azhipa, O., Semenov, I., Corey, S.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  11. Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli. Sweasy, J.B., Loeb, L.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  12. NuA4 subunit Yng2 function in intra-S-phase DNA damage response. Choy, J.S., Kron, S.J. Mol. Cell. Biol. (2002) [Pubmed]
  13. BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. Kaina, B., Ochs, K., Grösch, S., Fritz, G., Lips, J., Tomicic, M., Dunkern, T., Christmann, M. Prog. Nucleic Acid Res. Mol. Biol. (2001) [Pubmed]
  14. Selective depletion of human DNA-methyltransferase DNMT1 proteins by sulfonate-derived methylating agents. Chuang, L.S., Tan, E.H., Oh, H.K., Li, B.F. Cancer Res. (2002) [Pubmed]
  15. Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents. Klungland, A., Fairbairn, L., Watson, A.J., Margison, G.P., Seeberg, E. EMBO J. (1992) [Pubmed]
  16. Abnormal sensitivity of skin fibroblasts from familial polyposis patients to DNA alkylating agents. Barfknecht, T.R., Little, J.B. Cancer Res. (1982) [Pubmed]
  17. Diminished G1 checkpoint after gamma-irradiation and altered cell cycle regulation by insulin-like growth factor II overexpression. Zhang, L., Kim, M., Choi, Y.H., Goemans, B., Yeung, C., Hu, Z., Zhan, S., Seth, P., Helman, L.J. J. Biol. Chem. (1999) [Pubmed]
  18. High expression of a new marker PCA-1 in human prostate carcinoma. Konishi, N., Nakamura, M., Ishida, E., Shimada, K., Mitsui, E., Yoshikawa, R., Yamamoto, H., Tsujikawa, K. Clin. Cancer Res. (2005) [Pubmed]
  19. Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cells. Kuo, M.L., Meng, T.C., Lin, J.K. Carcinogenesis (1996) [Pubmed]
  20. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. Watanabe, S., Ichimura, T., Fujita, N., Tsuruzoe, S., Ohki, I., Shirakawa, M., Kawasuji, M., Nakao, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  21. Increased removal of 3-alkyladenine reduces the frequencies of hprt mutations induced by methyl- and ethylmethanesulfonate in Chinese hamster fibroblast cells. Klungland, A., Bjørås, M., Hoff, E., Seeberg, E. Nucleic Acids Res. (1994) [Pubmed]
  22. Methylating agents and DNA repair responses: methylated bases and sources of strand breaks. Wyatt, M.D., Pittman, D.L. Chem. Res. Toxicol. (2006) [Pubmed]
  23. Evidence for distinct kinase-mediated pathways in gadd gene responses. Carrier, F., Zhan, Q., Alamo, I., Hanaoka, F., Fornace, A.J. Biochem. Pharmacol. (1998) [Pubmed]
  24. Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay. Shibata, Y., Nakamura, T. J. Biol. Chem. (2002) [Pubmed]
  25. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Gasch, A.P., Huang, M., Metzner, S., Botstein, D., Elledge, S.J., Brown, P.O. Mol. Biol. Cell (2001) [Pubmed]
  26. Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment. Lee, M.R., Kim, S.H., Cho, H.J., Lee, K.Y., Moon, A.R., Jeong, H.G., Lee, J.S., Hyun, J.W., Chung, M.H., You, H.J. J. Biol. Chem. (2004) [Pubmed]
  27. Relationships between yeast Rad27 and Apn1 in response to apurinic/apyrimidinic (AP) sites in DNA. Wu, X., Wang, Z. Nucleic Acids Res. (1999) [Pubmed]
  28. DNA damaging agents increase the stability of interleukin-1 alpha, interleukin-1 beta, and interleukin-6 transcripts and the production of the relative proteins. Mallardo, M., Giordano, V., Dragonetti, E., Scala, G., Quinto, I. J. Biol. Chem. (1994) [Pubmed]
  29. Complementation studies with the repair-deficient uvrD3, uvrE156, and recL152 mutations in Escherichia coli. Siegel, E.C. Mol. Gen. Genet. (1981) [Pubmed]
  30. Cysteine adducts of human haemoglobin measured by isoelectric focusing in polyacrylamide gels with a non-linear pH gradient. Evelo, C.T., Niessen, H.J., Roelofs, H.M., Henderson, P.T. J. Chromatogr. (1987) [Pubmed]
  31. The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase. Laha, S., Das, S.P., Hajra, S., Sau, S., Sinha, P. Nucleic Acids Res. (2006) [Pubmed]
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