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Gene Review: 

ZMYND19  -  zinc finger, MYND-type containing 19

Homo sapiens

Synonyms: MCH-R1-interacting zinc finger protein, MIZIP, Melanin-concentrating hormone receptor 1-interacting zinc finger protein, Zinc finger MYND domain-containing protein 19
 
 
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High impact information on ZMYND19

  • This protein, characterized by a Myeloid translocation protein 8, Nervy, DEAF1 proteins (MYND) zinc-finger domain, is termed MCH-R1-interacting zinc-finger protein, MIZIP [1].
  • MIZIP is expressed in brain, testis and stomach, where expression of MCH and MCH-R1 was previously reported [1].
  • MIZIP gene organization in human (six exons on chromosome 9q34.3) and mouse is highly conserved, yet in rodents an additional exon is generated giving rise to alternatively spliced mRNAs [1].
  • MIZIP was originally identified as a highly conserved zinc-finger protein from human brain interacting with the C-terminus of the melanin-concentrating hormone receptor 1 [2].
  • Immunoprecipitation and immunocytochemistry analyses demonstrate that MIZIP binds to tubulin but not to cellular microtubules in vivo and that ectopic expression of MIZIP does not interfere with the overall structure of the microtubular cytoskeleton [2].
 

Analytical, diagnostic and therapeutic context of ZMYND19

References

  1. MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. Bächner, D., Kreienkamp, H.J., Richter, D. FEBS Lett. (2002) [Pubmed]
  2. MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with alpha- and beta-tubulin. Francke, F., Buck, F., Bächner, D. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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