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Gene Review

omp25  -  outer-membrane protein Omp25

Brucella suis 1330

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Disease relevance of omp25

  • The major difference found was between the omp25 gene of B. ovis and those of the other Brucella species; the B. ovis gene had a 36-bp deletion located at the 3' end of the gene [1].
  • Expression of the 25-kDa outer membrane protein (Omp25) in Brucella spp. or expression from the cloned omp25 gene in Escherichia coli cells was studied with a panel of anti-Omp25 monoclonal antibodies (MAbs) [1].

High impact information on omp25


Analytical, diagnostic and therapeutic context of omp25


  1. Nucleotide sequence and expression of the gene encoding the major 25-kilodalton outer membrane protein of Brucella ovis: Evidence for antigenic shift, compared with other Brucella species, due to a deletion in the gene. Cloeckaert, A., Verger, J.M., Grayon, M., Zygmunt, M.S., Grépinet, O. Infect. Immun. (1996) [Pubmed]
  2. Major outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages. Jubier-Maurin, V., Boigegrain, R.A., Cloeckaert, A., Gross, A., Alvarez-Martinez, M.T., Terraza, A., Liautard, J., Köhler, S., Rouot, B., Dornand, J., Liautard, J.P. Infect. Immun. (2001) [Pubmed]
  3. Restriction site polymorphism of the genes encoding the major 25 kDa and 36 kDa outer-membrane proteins of Brucella. Cloeckaert, A., Verger, J.M., Grayon, M., Grépinet, O. Microbiology (Reading, Engl.) (1995) [Pubmed]
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