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Gene Review: 

Idd20  -  insulin dependent diabetes susceptibility 20

Mus musculus

 
 
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High impact information on Idd20

  • A NOD-derived resistance allele at the Idd19 locus affects the final diabetes incidence observed in both models, while a novel locus, provisionally termed Idd20, appears to control Idd19 in an epistatic manner [1].
  • Our results suggest that the two Chromosome 6 susceptibility loci, Idd6 and Idd20, interact with the resistance locus Idd19 by regulating the activity of suppressor cells in the peripheral immune system [2].
 

Biological context of Idd20

  • The Idd20, Idd19, and Idd6 candidate regions fall respectively within genetically defined intervals of 4, 7, and 4.5 cM on mouse chromosome 6 [1].
 

Associations of Idd20 with chemical compounds

  • Both Idds are located on distal mouse Chromosome 6, and previous studies on NOD.C3H congenic strains have shown that C3H alleles at Idd20 can suppress the disease-promoting effects of C3H alleles at Idd19 in both spontaneous and cyclophosphamide-induced diabetes [2].

References

  1. Three loci on mouse chromosome 6 influence onset and final incidence of type I diabetes in NOD.C3H congenic strains. Rogner, U.C., Boitard, C., Morin, J., Melanitou, E., Avner, P. Genomics (2001) [Pubmed]
  2. Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction. Morin, J., Boitard, C., Vallois, D., Avner, P., Rogner, U.C. Mamm. Genome (2006) [Pubmed]
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