Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Idd6 - insulin dependent diabetes susceptibility 6

Mus musculus

Synonyms: Idd-6

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Idd6

The second was to produce a congenic strain carrying Idd6, a susceptibility locus that has been repeatedly mapped in the vicinity of the NKR-P1 gene cluster and the NK complex, to explore the impact of this locus upon autoimmune diabetes [1].

High impact information on Idd6

The Idd6 murine type 1 diabetes locus has been shown to control diabetes by regulating the protective activity of the peripheral immune system, as demonstrated by diabetes transfer assays using splenocytes [2].
The diabetes type 1 locus Idd6 modulates activity of CD4+CD25+ regulatory T-cells [3].
Our studies on disease resistance of the congenic mouse strain NOD.C3H 6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and suggest that a major mechanism by which the Idd6 locus modifies diabetes development is via modulation of regulatory T-cell activities [3].
Our data also implicate the Idd6 locus in controlling the balance between infiltrating lymphocytes and antigen-presenting cells within the pancreatic islet [3].
We confirm that the Idd6 region controls apoptosis resistance in immature thymocytes [4].

Biological context of Idd6

From our YAC contig, Idd6 would appear to localize within a ca. 1.5-Mb region on distal chromosome 6 [5].
This chromosomal region contains the diabetes susceptibility locus Idd6, suggesting that the apoptosis-resistance phenotype constitutes a pathogenesis factor in IDDM of NOD mice [6].

Associations of Idd6 with chemical compounds

We have previously reported that resistance of NOD immature thymocytes to depletion by dexamethazone (Dxm) maps to the Idd6 locus [4].

Other interactions of Idd6

A surprisingly large number of polymorphisms and amino acid changes were identified in both Lrmp and Bcat1 indicating that they are candidates for Idd6 [7].
Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6 [7].
Our results suggest that the two Chromosome 6 susceptibility loci, Idd6 and Idd20, interact with the resistance locus Idd19 by regulating the activity of suppressor cells in the peripheral immune system [8].
A genetic mapping study using an F2 intercross between the NOD and the C57BL/6 strains showed that a major locus controlling this trait is linked to the insulin-dependent diabetes susceptibility locus Idd6 [9].

References

Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex. Carnaud, C., Gombert, J., Donnars, O., Garchon, H., Herbelin, A. J. Immunol. (2001) [Pubmed]
Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6. Hung, M.S., Avner, P., Rogner, U.C. Hum. Mol. Genet. (2006) [Pubmed]
The diabetes type 1 locus Idd6 modulates activity of CD4+CD25+ regulatory T-cells. Rogner, U.C., Lepault, F., Gagnerault, M.C., Vallois, D., Morin, J., Avner, P., Boitard, C. Diabetes (2006) [Pubmed]
Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains. Bergman, M.L., Duarte, N., Campino, S., Lundholm, M., Motta, V., Lejon, K., Penha-Gonçalves, C., Holmberg, D. Diabetes (2003) [Pubmed]
Three loci on mouse chromosome 6 influence onset and final incidence of type I diabetes in NOD.C3H congenic strains. Rogner, U.C., Boitard, C., Morin, J., Melanitou, E., Avner, P. Genomics (2001) [Pubmed]
Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6. Penha-Gonçalves, C., Leijon, K., Persson, L., Holmberg, D. Genomics (1995) [Pubmed]
Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6. Grimm, C.H., Rogner, U.C., Avner, P. Autoimmunity (2003) [Pubmed]
Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction. Morin, J., Boitard, C., Vallois, D., Avner, P., Rogner, U.C. Mamm. Genome (2006) [Pubmed]
Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region. Bergman, M.L., Penha-Gonçalves, C., Lejon, K., Holmberg, D. Diabetologia (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.