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Gene Review

MIA2  -  melanoma inhibitory activity 2

Homo sapiens

Synonyms: FLJ22404, Melanoma inhibitory activity protein 2
 
 
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Disease relevance of MIA2

  • MIA2 mRNA levels were significantly higher in patients with severe fibrosis or inflammation than in patients with less severe fibrosis or inflammation [1].
  • The increased transcription in more severe chronic liver disease suggests that MIA2 may serve as a marker of hepatic disease activity and severity [1].
  • In accordance with these results, MIA2 mRNA was found to be increased in liver tissue of patients with chronic hepatitis C infection compared with controls [1].
  • In contrast, only low MIA2 expression levels were detected in most HCC and hepatoma cell lines [2].
 

High impact information on MIA2

 

Analytical, diagnostic and therapeutic context of MIA2

References

  1. Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes. Bosserhoff, A.K., Moser, M., Schölmerich, J., Buettner, R., Hellerbrand, C. J. Biol. Chem. (2003) [Pubmed]
  2. In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers. Hellerbrand, C., Bataille, F., Schlegel, J., Hartmann, A., Mühlbauer, M., Schölmerich, J., Büttner, R., Hofstädter, F., Bosserhoff, A.K. Liver Int. (2005) [Pubmed]
  3. Characterization and expression pattern of the novel MIA homolog TANGO. Bosserhoff, A.K., Moser, M., Buettner, R. Gene Expr. Patterns (2004) [Pubmed]
 
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