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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TMC2  -  transmembrane channel-like 2

Homo sapiens

Synonyms: C20orf145, Transmembrane channel-like protein 2, Transmembrane cochlear-expressed protein 2, UNQ907/PRO1928, dJ686C3.3
 
 
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High impact information on TMC2

  • TMC1 and TMC2 on chromosome 20p13 are members of a gene family predicted to encode transmembrane proteins [1].
  • Here we show that TMC-2 inhibited DP IV activity of CD26 immunoprecipitated from T cell lysates, and also inhibited proliferative responses of T cells to specific antigen or anti-CD3 antibody [2].
  • Because the effects of TMC-2 on T cells were reversible and it was not toxic at the concentrations used, TMC-2 may be a candidate novel therapeutic agent for rheumatoid arthritis [2].
  • These results suggest that modulation of CD45 PTPase activity might be responsible for functional suppression of T cells by TMC-2 [2].
  • To elucidate the mechanism of TMC-2 antiarthritic activity, we have studied its effects on T cell function [2].
 

Other interactions of TMC2

  • Previously we have identified a DP IV inhibitor, designated TMC-2, found in culture supernatant of Aspergillus oryzae [2].
 

Analytical, diagnostic and therapeutic context of TMC2

References

  1. Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Kurima, K., Peters, L.M., Yang, Y., Riazuddin, S., Ahmed, Z.M., Naz, S., Arnaud, D., Drury, S., Mo, J., Makishima, T., Ghosh, M., Menon, P.S., Deshmukh, D., Oddoux, C., Ostrer, H., Khan, S., Riazuddin, S., Deininger, P.L., Hampton, L.L., Sullivan, S.L., Battey, J.F., Keats, B.J., Wilcox, E.R., Friedman, T.B., Griffith, A.J. Nat. Genet. (2002) [Pubmed]
  2. Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis. Williams, Y.N., Baba, H., Hayashi, S., Ikai, H., Sugita, T., Tanaka, S., Miyasaka, N., Kubota, T. Clin. Exp. Immunol. (2003) [Pubmed]
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