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Gene Review

RFFL  -  ring finger and FYVE-like domain...

Homo sapiens

Synonyms: CARP-2, CARP2, Caspase regulator CARP2, Caspases-8 and-10-associated RING finger protein 2, E3 ubiquitin-protein ligase rififylin, ...
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High impact information on RFFL

  • In contrast, the amino-terminal domain of Rffl, which shows similarities with the phosphatidylinositol-3-phosphate-binding FYVE finger, is critical for the recruitment of Rffl to recycling endocytic membranes and for the inhibition of recycling, albeit in a manner that is independent of PtdIns(3)-kinase activity [1].
  • Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane [1].
  • Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2 [2].


  1. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Coumailleau, F., Das, V., Alcover, A., Raposo, G., Vandormael-Pournin, S., Le Bras, S., Baldacci, P., Dautry-Varsat, A., Babinet, C., Cohen-Tannoudji, M. Mol. Biol. Cell (2004) [Pubmed]
  2. Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2. Tibbetts, M.D., Shiozaki, E.N., Gu, L., McDonald, E.R., El-Deiry, W.S., Shi, Y. Structure (Camb.) (2004) [Pubmed]
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