The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

RFFL  -  ring finger and FYVE-like domain...

Homo sapiens

Synonyms: CARP-2, CARP2, Caspase regulator CARP2, Caspases-8 and-10-associated RING finger protein 2, E3 ubiquitin-protein ligase rififylin, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on RFFL

  • In contrast, the amino-terminal domain of Rffl, which shows similarities with the phosphatidylinositol-3-phosphate-binding FYVE finger, is critical for the recruitment of Rffl to recycling endocytic membranes and for the inhibition of recycling, albeit in a manner that is independent of PtdIns(3)-kinase activity [1].
  • Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane [1].
  • Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2 [2].

References

  1. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Coumailleau, F., Das, V., Alcover, A., Raposo, G., Vandormael-Pournin, S., Le Bras, S., Baldacci, P., Dautry-Varsat, A., Babinet, C., Cohen-Tannoudji, M. Mol. Biol. Cell (2004) [Pubmed]
  2. Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2. Tibbetts, M.D., Shiozaki, E.N., Gu, L., McDonald, E.R., El-Deiry, W.S., Shi, Y. Structure (Camb.) (2004) [Pubmed]
 
WikiGenes - Universities