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Chemical Compound Review

AC1OAGK2     (2R)-2-[[hydroxy- [(1S,2R,3S,4S,5R,6R)-2,3...

Synonyms: HMDB03850, Phosphatidylinositol 3-phosphate, 1-phosphatidyl-1D-myo-inositol 3-phosphate
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Disease relevance of Phosphatidylinositol 3-phosphate


High impact information on Phosphatidylinositol 3-phosphate


Chemical compound and disease context of Phosphatidylinositol 3-phosphate


Biological context of Phosphatidylinositol 3-phosphate


Anatomical context of Phosphatidylinositol 3-phosphate


Associations of Phosphatidylinositol 3-phosphate with other chemical compounds


Gene context of Phosphatidylinositol 3-phosphate


Analytical, diagnostic and therapeutic context of Phosphatidylinositol 3-phosphate


  1. Endosome-to-cytosol transport of viral nucleocapsids. Le Blanc, I., Luyet, P.P., Pons, V., Ferguson, C., Emans, N., Petiot, A., Mayran, N., Demaurex, N., Fauré, J., Sadoul, R., Parton, R.G., Gruenberg, J. Nat. Cell Biol. (2005) [Pubmed]
  2. Inaugural article: myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Taylor, G.S., Maehama, T., Dixon, J.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy. Tosch, V., Rohde, H.M., Tronch??re, H., Zanoteli, E., Monroy, N., Kretz, C., Dondaine, N., Payrastre, B., Mandel, J.L., Laporte, J. Hum. Mol. Genet. (2006) [Pubmed]
  4. Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer. Frattini, M., Signoroni, S., Pilotti, S., Bertario, L., Benvenuti, S., Zanon, C., Bardelli, A., Pierotti, M.A. Cancer Res. (2005) [Pubmed]
  5. Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles. Chua, J., Deretic, V. J. Biol. Chem. (2004) [Pubmed]
  6. Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Slessareva, J.E., Routt, S.M., Temple, B., Bankaitis, V.A., Dohlman, H.G. Cell (2006) [Pubmed]
  7. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Misra, S., Hurley, J.H. Cell (1999) [Pubmed]
  8. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Franke, T.F., Yang, S.I., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R., Tsichlis, P.N. Cell (1995) [Pubmed]
  9. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Auger, K.R., Serunian, L.A., Soltoff, S.P., Libby, P., Cantley, L.C. Cell (1989) [Pubmed]
  10. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Simonsen, A., Lippé, R., Christoforidis, S., Gaullier, J.M., Brech, A., Callaghan, J., Toh, B.H., Murphy, C., Zerial, M., Stenmark, H. Nature (1998) [Pubmed]
  11. Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. Lips, D.L., Majerus, P.W., Gorga, F.R., Young, A.T., Benjamin, T.L. J. Biol. Chem. (1989) [Pubmed]
  12. Regulation of phosphoinositide-3-kinase by G protein beta gamma subunits in a rat osteosarcoma cell line. Morris, A.J., Rudge, S.A., Mahlum, C.E., Jenco, J.M. Mol. Pharmacol. (1995) [Pubmed]
  13. Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. Maffucci, T., Cooke, F.T., Foster, F.M., Traer, C.J., Fry, M.J., Falasca, M. J. Cell Biol. (2005) [Pubmed]
  14. PI3P signaling regulates receptor sorting but not transport in the endosomal pathway. Petiot, A., Faure, J., Stenmark, H., Gruenberg, J. J. Cell Biol. (2003) [Pubmed]
  15. Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity. Nandurkar, H.H., Caldwell, K.K., Whisstock, J.C., Layton, M.J., Gaudet, E.A., Norris, F.A., Majerus, P.W., Mitchell, C.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  16. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa, A., Leonard, D., Murphy, S., Hayes, S., Soto, M., Fogarty, K., Standley, C., Bellve, K., Lambright, D., Mello, C., Corvera, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  17. TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Heymont, J., Berenfeld, L., Collins, J., Kaganovich, A., Maynes, B., Moulin, A., Ratskovskaya, I., Poon, P.P., Johnston, G.C., Kamenetsky, M., DeSilva, J., Sun, H., Petsko, G.A., Engebrecht, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  18. Structural mechanism of endosome docking by the FYVE domain. Kutateladze, T., Overduin, M. Science (2001) [Pubmed]
  19. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Cheever, M.L., Sato, T.K., de Beer, T., Kutateladze, T.G., Emr, S.D., Overduin, M. Nat. Cell Biol. (2001) [Pubmed]
  20. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Kanai, F., Liu, H., Field, S.J., Akbary, H., Matsuo, T., Brown, G.E., Cantley, L.C., Yaffe, M.B. Nat. Cell Biol. (2001) [Pubmed]
  21. The uniformity of phagosome maturation in macrophages. Henry, R.M., Hoppe, A.D., Joshi, N., Swanson, J.A. J. Cell Biol. (2004) [Pubmed]
  22. Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. Roggo, L., Bernard, V., Kovacs, A.L., Rose, A.M., Savoy, F., Zetka, M., Wymann, M.P., Müller, F. EMBO J. (2002) [Pubmed]
  23. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. Fratti, R.A., Backer, J.M., Gruenberg, J., Corvera, S., Deretic, V. J. Cell Biol. (2001) [Pubmed]
  24. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki, Y., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  25. Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Kong, A.M., Horan, K.A., Sriratana, A., Bailey, C.G., Collyer, L.J., Nandurkar, H.H., Shisheva, A., Layton, M.J., Rasko, J.E., Rowe, T., Mitchell, C.A. Mol. Cell. Biol. (2006) [Pubmed]
  26. Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Goi, T., Rusanescu, G., Urano, T., Feig, L.A. Mol. Cell. Biol. (1999) [Pubmed]
  27. Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. Berger, P., Berger, I., Schaffitzel, C., Tersar, K., Volkmer, B., Suter, U. Hum. Mol. Genet. (2006) [Pubmed]
  28. Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Gary, J.D., Sato, T.K., Stefan, C.J., Bonangelino, C.J., Weisman, L.S., Emr, S.D. Mol. Biol. Cell (2002) [Pubmed]
  29. The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting. Tall, G.G., Hama, H., DeWald, D.B., Horazdovsky, B.F. Mol. Biol. Cell (1999) [Pubmed]
  30. Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. Nakagawa, T., Goto, K., Kondo, H. J. Biol. Chem. (1996) [Pubmed]
  31. Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase). Prasad, K.V., Kapeller, R., Janssen, O., Duke-Cohan, J.S., Repke, H., Cantley, L.C., Rudd, C.E. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1993) [Pubmed]
  32. Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Nasuhoglu, C., Feng, S., Mao, J., Yamamoto, M., Yin, H.L., Earnest, S., Barylko, B., Albanesi, J.P., Hilgemann, D.W. Anal. Biochem. (2002) [Pubmed]
  33. Entamoeba histolytica: FYVE-finger domains, phosphatidylinositol 3-phosphate biosensors, associate with phagosomes but not fluid filled endosomes. Powell, R.R., Welter, B.H., Hwu, R., Bowersox, B., Attaway, C., Temesvari, L.A. Exp. Parasitol. (2006) [Pubmed]
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