Disease relevance of Apoc1

• It has recently been shown that septic HDL is almost depleted from apolipoprotein CI (apoCI), suggesting that apoCI may be a protective factor in sepsis [1].

High impact information on Apoc1

• We have generated transgenic mice over-expressing human apolipoprotein CI (apo CI) using the native gene joined to the downstream 154-bp liver-specific enhancer that we defined for apo E [2].
• The impact of apolipoprotein C-I (apoC-I) deficiency on hepatic lipid metabolism was addressed in mice in the presence or the absence of cholesteryl ester transfer protein (CETP) [3].
• The Apoc1 gene is part of the Apoe-c1-c2 gene cluster and is located 3.4 kb 3' of the Apoe gene [4].
• The mouse Apoc1 cDNA contains an open reading frame encoding a protein of 88 amino acids, including a signal peptide of 26 amino acid residues [4].
• The mouse Apoc1 gene spans a region of approximately 3.3 kb and consists of four exons [4].

Chemical compound and disease context of Apoc1

• Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis [1].

Biological context of Apoc1

• We assessed whether physiological endogenous apoC-I levels are sufficient to modulate plasma lipid levels independently of effects of apoE on lipid metabolism by comparing apolipoprotein E gene-deficient/apolipoprotein C-I gene-deficient (apoe-/-apoc1-/-), apoe-/-apoc1+/-, and apoe-/-apoc1+/+ mice [5].

Anatomical context of Apoc1

• OBJECTIVES: Recently, we reported that exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease is associated with enrichment of remnant lipoproteins with apolipoprotein C-I (apoC-I) [6].

Associations of Apoc1 with chemical compounds

• We have isolated and characterized cDNA and genomic clones containing the mouse apolipoprotein C1 (Apoc1) gene [4].

Other interactions of Apoc1

• First, we tested whether this distinction is due to additional mutation of the Apoc1 and/or Apoc2 genes in KOR-Apoe(shl) [7].

References