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MeSH Review

Lipid Metabolism

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Disease relevance of Lipid Metabolism


Psychiatry related information on Lipid Metabolism


High impact information on Lipid Metabolism


Chemical compound and disease context of Lipid Metabolism


Biological context of Lipid Metabolism


Anatomical context of Lipid Metabolism


Associations of Lipid Metabolism with chemical compounds

  • In contrast, captopril appears to have beneficial or no effects on glucose and lipid metabolism [31].
  • Zebrafish are a valuable model for mammalian lipid metabolism; larvae process lipids similarly through the intestine and hepatobiliary system and respond to drugs that block cholesterol synthesis in humans [32].
  • Because of the apparent restriction of adipsin synthesis to tissues highly active in lipid metabolism, its presence in serum, and its modulation in altered metabolic states, this molecule may play a previously unrecognized role in systemic lipid metabolism or energy balance [33].
  • This study documents the role of the retinoid signaling pathway in formation and maintenance of a functional epidermis and provides the first evidence that this is mediated in part by modulation of lipid metabolism [34].
  • Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse [35].

Gene context of Lipid Metabolism

  • The obese Il6-/- mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment [36].
  • Lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins [37].
  • PPARalpha is a nuclear receptor controlling lipid metabolism and inflammation, but its role in the regulation of SMC growth remains to be established [38].
  • The role of FAA1 in cellular lipid metabolism and protein N-myristoylation was therefore assessed in strains subjected to biochemical or genetic blockade of FAS [39].
  • The role that noncoding variable sites play in the explanation of pleiotropic effects on different measures of lipid metabolism reveals that both regulatory and structural functional variation in the APOE gene influences measures of lipid metabolism [40].

Analytical, diagnostic and therapeutic context of Lipid Metabolism


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  17. Effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists, and alpha-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension. Giordano, M., Matsuda, M., Sanders, L., Canessa, M.L., DeFronzo, R.A. Diabetes (1995) [Pubmed]
  18. Lipodystrophy defined by a clinical score in HIV-infected men on highly active antiretroviral therapy: correlation between dyslipidaemia and steroid hormone alterations. Christeff, N., Melchior, J.C., de Truchis, P., Perronne, C., Nunez, E.A., Gougeon, M.L. AIDS (1999) [Pubmed]
  19. A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol. Rosmond, R., Chagnon, M., Bouchard, C., Björntorp, P. Diabetologia (2001) [Pubmed]
  20. Effect of prazosin treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. Swislocki, A.L., Hoffman, B.B., Sheu, W.H., Chen, Y.D., Reaven, G.M. Am. J. Med. (1989) [Pubmed]
  21. Disruption of cholesterol homeostasis by plant sterols. Yang, C., Yu, L., Li, W., Xu, F., Cohen, J.C., Hobbs, H.H. J. Clin. Invest. (2004) [Pubmed]
  22. Isolation and characterization of glycosaminoglycans in human plasma. Staprans, I., Felts, J.M. J. Clin. Invest. (1985) [Pubmed]
  23. Insulin-like growth factor-1 therapy in diabetes: physiologic basis, clinical benefits, and risks. Kolaczynski, J.W., Caro, J.F. Ann. Intern. Med. (1994) [Pubmed]
  24. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Foretz, M., Guichard, C., Ferré, P., Foufelle, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  25. Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function. Venkov, C.D., Rankin, A.B., Vaughan, D.E. Circulation (1996) [Pubmed]
  26. Adiponectin acts in the brain to decrease body weight. Qi, Y., Takahashi, N., Hileman, S.M., Patel, H.R., Berg, A.H., Pajvani, U.B., Scherer, P.E., Ahima, R.S. Nat. Med. (2004) [Pubmed]
  27. Acute stimulation of glucose metabolism in mice by leptin treatment. Kamohara, S., Burcelin, R., Halaas, J.L., Friedman, J.M., Charron, M.J. Nature (1997) [Pubmed]
  28. Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase. Hawkins, P.T., Jackson, T.R., Stephens, L.R. Nature (1992) [Pubmed]
  29. Calcium/calmodulin-mediated action of calcitonin on lipid metabolism in rats. Nishizawa, Y., Okui, Y., Inaba, M., Okuno, S., Yukioka, K., Miki, T., Watanabe, Y., Morii, H. J. Clin. Invest. (1988) [Pubmed]
  30. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. Lefebvre, P., Chinetti, G., Fruchart, J.C., Staels, B. J. Clin. Invest. (2006) [Pubmed]
  31. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. Pollare, T., Lithell, H., Berne, C. N. Engl. J. Med. (1989) [Pubmed]
  32. Genetic analysis of digestive physiology using fluorescent phospholipid reporters. Farber, S.A., Pack, M., Ho, S.Y., Johnson, I.D., Wagner, D.S., Dosch, R., Mullins, M.C., Hendrickson, H.S., Hendrickson, E.K., Halpern, M.E. Science (2001) [Pubmed]
  33. Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Cook, K.S., Min, H.Y., Johnson, D., Chaplinsky, R.J., Flier, J.S., Hunt, C.R., Spiegelman, B.M. Science (1987) [Pubmed]
  34. Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Imakado, S., Bickenbach, J.R., Bundman, D.S., Rothnagel, J.A., Attar, P.S., Wang, X.J., Walczak, V.R., Wisniewski, S., Pote, J., Gordon, J.S. Genes Dev. (1995) [Pubmed]
  35. Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Costello, P.S., Gallagher, M., Cantrell, D.A. Nat. Immunol. (2002) [Pubmed]
  36. Interleukin-6-deficient mice develop mature-onset obesity. Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S.L., Ohlsson, C., Jansson, J.O. Nat. Med. (2002) [Pubmed]
  37. Human lipoprotein lipase complementary DNA sequence. Wion, K.L., Kirchgessner, T.G., Lusis, A.J., Schotz, M.C., Lawn, R.M. Science (1987) [Pubmed]
  38. PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a. Gizard, F., Amant, C., Barbier, O., Bellosta, S., Robillard, R., Percevault, F., Sevestre, H., Krimpenfort, P., Corsini, A., Rochette, J., Glineur, C., Fruchart, J.C., Torpier, G., Staels, B. J. Clin. Invest. (2005) [Pubmed]
  39. Isolation of a Saccharomyces cerevisiae long chain fatty acyl:CoA synthetase gene (FAA1) and assessment of its role in protein N-myristoylation. Duronio, R.J., Knoll, L.J., Gordon, J.I. J. Cell Biol. (1992) [Pubmed]
  40. Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism. Stengård, J.H., Clark, A.G., Weiss, K.M., Kardia, S., Nickerson, D.A., Salomaa, V., Ehnholm, C., Boerwinkle, E., Sing, C.F. Am. J. Hum. Genet. (2002) [Pubmed]
  41. Relationship between insulin-mediated glucose disposal and lipid metabolism in man. Lillioja, S., Bogardus, C., Mott, D.M., Kennedy, A.L., Knowler, W.C., Howard, B.V. J. Clin. Invest. (1985) [Pubmed]
  42. Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice. Wang, L.C., Nassir, F., Liu, Z.Y., Ling, L., Kuo, F., Crowell, T., Olson, D., Davidson, N.O., Burkly, L.C. Gastroenterology (2002) [Pubmed]
  43. Metformin normalizes nonoxidative glucose metabolism in insulin-resistant normoglycemic first-degree relatives of patients with NIDDM. Widén, E.I., Eriksson, J.G., Groop, L.C. Diabetes (1992) [Pubmed]
  44. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Cunha-Neto, E., Dzau, V.J., Allen, P.D., Stamatiou, D., Benvenutti, L., Higuchi, M.L., Koyama, N.S., Silva, J.S., Kalil, J., Liew, C.C. Am. J. Pathol. (2005) [Pubmed]
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