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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Klf16  -  Kruppel-like factor 16

Mus musculus

Synonyms: AI843742, BTE-binding protein 4, BTEB4, Basic transcription element-binding protein 4, Bteb4, ...
 
 
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High impact information on Klf16

  • These findings confirm the tissue-specific activity of the DRRF promoter and suggest that this gene shares structural and functional similarities with the dopamine receptor genes that it regulates [1].
  • Comparison among cell types revealed strong transcriptional activity of the DRRF promoter in neuronal NB41A3 cells and moderate activity in hepatic HepG2 and renal OK cells, but none in skeletal muscle C2C12 or glial C6 cells [1].
  • This pattern of DRRF distribution during embryogenesis overlaps with that found in the adult brain, and with the expression profile of dopamine receptors both in the adult and during development [2].
  • Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor) [2].
  • DRRF expression is also found in particular brain regions, such as the neopallial cortex, olfactory lobe and corpus striatum [2].

References

  1. Genomic organization and promoter characterization of the murine dopamine receptor regulating factor (DRRF) gene. Lee, S.H., Kim, Y.M., Yajima, S., Ha, J.M., Ha, B.J., Kim, O.S., Ohsawa, K., Mouradian, M.M. Gene (2003) [Pubmed]
  2. Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor). D'Souza, U.M., Lammers, C.H., Hwang, C.K., Yajima, S., Mouradian, M.M. Mech. Dev. (2002) [Pubmed]
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