Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

folA - dihydrofolate reductase

Enterococcus faecalis V583

Gleisner, J.M. et al., Nair, M.G. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of folA

Compound 2 was a very powerful inhibitor of DCM-resistant lactobacillus casei dihydrofolate reductase [1].
Dihydrofolate reductase from the amethopterin-resistant mutant (strain A) of Streptococcus faecium var [2].

High impact information on folA

The structure of dihydrofolate reductase. Identification of methionine residues carboxymethylated by iodoacetate with loss of catalytic activity [2].

References

Folate analogues altered in the C9-N10 bridge region. 10-Oxafolic acid and 10-oxaaminopterin. Nair, M.G., Campbell, P.T. J. Med. Chem. (1976) [Pubmed]
The structure of dihydrofolate reductase. Identification of methionine residues carboxymethylated by iodoacetate with loss of catalytic activity. Gleisner, J.M., Blakley, R.L. Eur. J. Biochem. (1975) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.