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Disease relevance of Lactobacillus


High impact information on Lactobacillus

  • In normal vaginal fluid, lactate was the predominant acid, and the predominant organisms were lactobacillus and streptococcus species (lactate producers) [6].
  • Pyruvate oxidase from Lactobacillus plantarum is a tetrameric enzyme that decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate [7].
  • The atomic structure of thymidylate synthase from Lactobacillus casei was determined at 3 angstrom resolution [8].
  • A study of folate in 526 women attending a family-planning clinic demonstrated, both with the Lactobacillus casei assay and with a new radioassay, that the mean serum folate level for women taking oral contraceptives was not significantly lower than that for women in a control group [9].
  • The addition of viable Lactobacillus acidophilus supplements to the diet of omnivores significantly decreased fecal bacterial beta-glucuronidase and nitroreductase activities [10].

Chemical compound and disease context of Lactobacillus


Biological context of Lactobacillus


Anatomical context of Lactobacillus


Gene context of Lactobacillus


Analytical, diagnostic and therapeutic context of Lactobacillus


  1. Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction. Verdú, E.F., Bercík, P., Bergonzelli, G.E., Huang, X.X., Blennerhasset, P., Rochat, F., Fiaux, M., Mansourian, R., Corthésy-Theulaz, I., Collins, S.M. Gastroenterology (2004) [Pubmed]
  2. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Kalliomäki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P., Isolauri, E. Lancet (2001) [Pubmed]
  3. The effects of Lactobacillus strains and oat fiber on methotrexate-induced enterocolitis in rats. Mao, Y., Nobaek, S., Kasravi, B., Adawi, D., Stenram, U., Molin, G., Jeppsson, B. Gastroenterology (1996) [Pubmed]
  4. Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure. Garrow, T.A., Admon, A., Shane, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4. Chang, T.L., Chang, C.H., Simpson, D.A., Xu, Q., Martin, P.K., Lagenaur, L.A., Schoolnik, G.K., Ho, D.D., Hillier, S.L., Holodniy, M., Lewicki, J.A., Lee, P.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Anaerobic bacteria in nonspecific vaginitis. Spiegel, C.A., Amsel, R., Eschenbach, D., Schoenknecht, F., Holmes, K.K. N. Engl. J. Med. (1980) [Pubmed]
  7. Structure of the thiamine- and flavin-dependent enzyme pyruvate oxidase. Muller, Y.A., Schulz, G.E. Science (1993) [Pubmed]
  8. Atomic structure of thymidylate synthase: target for rational drug design. Hardy, L.W., Finer-Moore, J.S., Montfort, W.R., Jones, M.O., Santi, D.V., Stroud, R.M. Science (1987) [Pubmed]
  9. Oral contraceptives, serum folate, and hematologic status. Paine, C.J., Grafton, W.D., Dickson, V.L., Eichner, E.R. JAMA (1975) [Pubmed]
  10. Effect of diet and Lactobacillus acidophilus supplements on human fecal bacterial enzymes. Goldin, B.R., Swenson, L., Dwyer, J., Sexton, M., Gorbach, S.L. J. Natl. Cancer Inst. (1980) [Pubmed]
  11. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. Goldin, B.R., Gorbach, S.L. J. Natl. Cancer Inst. (1980) [Pubmed]
  12. Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Madsen, K.L., Doyle, J.S., Jewell, L.D., Tavernini, M.M., Fedorak, R.N. Gastroenterology (1999) [Pubmed]
  13. The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K. Chaillou, S., Champomier-Vergès, M.C., Cornet, M., Crutz-Le Coq, A.M., Dudez, A.M., Martin, V., Beaufils, S., Darbon-Rongère, E., Bossy, R., Loux, V., Zagorec, M. Nat. Biotechnol. (2005) [Pubmed]
  14. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Altermann, E., Russell, W.M., Azcarate-Peril, M.A., Barrangou, R., Buck, B.L., McAuliffe, O., Souther, N., Dobson, A., Duong, T., Callanan, M., Lick, S., Hamrick, A., Cano, R., Klaenhammer, T.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. ATP-dependent phosphorylation of serine-46 in the phosphocarrier protein HPr regulates lactose/H+ symport in Lactobacillus brevis. Ye, J.J., Reizer, J., Cui, X., Saier, M.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Cooperative binding of lactose and the phosphorylated phosphocarrier protein HPr(Ser-P) to the lactose/H+ symport permease of Lactobacillus brevis. Ye, J.J., Saier, M.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Effect of Lactobacillus supplementation with and without arginine on liver damage and bacterial translocation in an acute liver injury model in the rat. Adawi, D., Kasravi, F.B., Molin, G., Jeppsson, B. Hepatology (1997) [Pubmed]
  18. Anticonvulsants, folate levels, and pregnancy outcome: a prospective study. Dansky, L.V., Andermann, E., Rosenblatt, D., Sherwin, A.L., Andermann, F. Ann. Neurol. (1987) [Pubmed]
  19. Cloning and nucleotide sequence of wild type and a mutant histidine decarboxylase from Lactobacillus 30a. Vanderslice, P., Copeland, W.C., Robertus, J.D. J. Biol. Chem. (1986) [Pubmed]
  20. Properties of a thioredoxin purified from rabbit bone marrow which fails to serve as a hydrogen donor for the homologous ribonucleotide reductase. Hopper, S., Iurlano, D. J. Biol. Chem. (1983) [Pubmed]
  21. Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Mack, D.R., Ahrne, S., Hyde, L., Wei, S., Hollingsworth, M.A. Gut (2003) [Pubmed]
  22. Inhibition of macrophage migration by muramyl peptides. Nagao, S., Tanaka, A., Yamamoto, Y., Koga, T., Onoue, K., Shiba, T., Kusumoto, K., Kotani, S. Infect. Immun. (1979) [Pubmed]
  23. Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice. Wagner, R.D., Pierson, C., Warner, T., Dohnalek, M., Farmer, J., Roberts, L., Hilty, M., Balish, E. Infect. Immun. (1997) [Pubmed]
  24. Deoxycytidine kinase and deoxyguanosine kinase of Lactobacillus acidophilus R-26 are colinear products of a single gene. Ma, N., Ikeda, S., Guo, S., Fieno, A., Park, I., Grimme, S., Ikeda, T., Ives, D.H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  25. Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Verdú, E.F., Bercik, P., Verma-Gandhu, M., Huang, X.X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., Collins, S.M. Gut (2006) [Pubmed]
  26. Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Ma, D., Forsythe, P., Bienenstock, J. Infect. Immun. (2004) [Pubmed]
  27. Lactobacillus rhamnosus GG decreases TNF-alpha production in lipopolysaccharide-activated murine macrophages by a contact-independent mechanism. Peña, J.A., Versalovic, J. Cell. Microbiol. (2003) [Pubmed]
  28. Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations. Tanaka, M., Kimura, K., Yoshida, S. Cancer Res. (1983) [Pubmed]
  29. Molecular cloning of manganese catalase from Lactobacillus plantarum. Igarashi, T., Kono, Y., Tanaka, K. J. Biol. Chem. (1996) [Pubmed]
  30. Crystallization and molecular symmetry of ornithine decarboxylase from Lactobacillus 30a. Momany, C., Hackert, M.L. J. Biol. Chem. (1989) [Pubmed]
  31. Saturation site-directed mutagenesis of thymidylate synthase. Climie, S., Ruiz-Perez, L., Gonzalez-Pacanowska, D., Prapunwattana, P., Cho, S.W., Stroud, R., Santi, D.V. J. Biol. Chem. (1990) [Pubmed]
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