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Chemical Compound Review

IODOACETIC ACID     2-iodoethanoic acid

Synonyms: iodoacetate, Iodoaceticacid, sJPhLQVIKTp@, CH2ICOOH, CCRIS 667, ...
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Disease relevance of iodoacetate

  • Unexpectedly, we found that after 'chemical hypoxia' with cyanide and iodoacetate, cytosolic free Ca2+ does not change during bleb formation or before loss of cellular viability [1].
  • Either inhibition or enhancement of the spontaneous lymphoma exhibited by AKR mice was observed after treatment with different dosages of the sulfhydryl inhibitor, sodium iodoacetate [2].
  • Pretreatment with iodoacetate significantly advanced these events (1.9 +/- 0.7, 3.6 +/- 0.9, and 1.9 +/- 0.2 minutes of ischemia, respectively) [3].
  • The results indicated that HPD-induced photosensitization had little additive effects to oligomycin-sensitive ATP production, whereas significant further reduction in ATP levels was obtained by HPD-induced photosensitization in the presence of iodoacetate [4].
  • Exposure of cultured hepatoma 1c1c7 cells to KCN and iodoacetate, to produce chemical anoxia, caused a rapid and sustained increase in cytosolic-free Ca2+ concentration, which was associated with depletion of intracellular ATP and glutathione [5].

Psychiatry related information on iodoacetate


High impact information on iodoacetate

  • Despite the fact that glycolytic flux had been blocked both by iodoacetate and by absence of substrate, end-diastolic left ventricular pressure (EDP) remained unchanged (P > 0.15, n = 6) [8].
  • Glycogen was effectively depleted after 15-min perfusion with glucagon (2 mg/liter), as verified by the lack of rise in [SP] during exposure to iodoacetate (100 microM) in substrate-free perfusate [8].
  • This study was initiated to characterize the effects of synthetic inhibitors of phospholipase activities using a cultured myocardial cell model in which arachidonic acid is liberated after treatment with the metabolic inhibitor, iodoacetate [9].
  • Inhibiting glycolysis with iodoacetate (IAA) (10(-3)M) had a much smaller suppressant effect on tension (28 +/- 24%) but markedly increased [K+]0 accumulation (by 1.8 +/- 1.1 mM) at 10 min [10].
  • The shortening of action potential duration was not significantly different for the four interventions. pH0 increased slightly during IAA (+0.04-+0.06 U) and fell during the other interventions (-0.10--0.16 U), but this did not account for the differences in [K+]0 accumulation and tension between inhibition of glycolytic vs. oxidative metabolism [10].

Chemical compound and disease context of iodoacetate


Biological context of iodoacetate


Anatomical context of iodoacetate


Associations of iodoacetate with other chemical compounds


Gene context of iodoacetate


Analytical, diagnostic and therapeutic context of iodoacetate


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  2. Iodoacetate-induced inhibition and enhancement of spontaneous leukemia in AKR mice. Rheins, M.S., Filppi, J.A. J. Natl. Cancer Inst. (1977) [Pubmed]
  3. Intracellular Ca2+, intercellular electrical coupling, and mechanical activity in ischemic rabbit papillary muscle. Effects of preconditioning and metabolic blockade. Dekker, L.R., Fiolet, J.W., VanBavel, E., Coronel, R., Opthof, T., Spaan, J.A., Janse, M.J. Circ. Res. (1996) [Pubmed]
  4. Relationship of mitochondrial function and cellular adenosine triphosphate levels to hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors. Hilf, R., Murant, R.S., Narayanan, U., Gibson, S.L. Cancer Res. (1986) [Pubmed]
  5. Cytosolic-free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia. Nicotera, P., Thor, H., Orrenius, S. FASEB J. (1989) [Pubmed]
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  9. Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion. Sen, A., Miller, J.C., Reynolds, R., Willerson, J.T., Buja, L.M., Chien, K.R. J. Clin. Invest. (1988) [Pubmed]
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  15. Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia. Bickler, P.E., Hansen, B.M. Neuropharmacology (1996) [Pubmed]
  16. In vivo protein secretion by lung. Evidence for active secretion and interspecies differences. Massaro, D. J. Clin. Invest. (1975) [Pubmed]
  17. Metabolic control of circulation. Effects of iodoacetate and fluoroacetate. Liang, C.S. J. Clin. Invest. (1977) [Pubmed]
  18. A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity. Tamura, T., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  19. m3G cap hypermethylation of U1 small nuclear ribonucleoprotein (snRNP) in vitro: evidence that the U1 small nuclear RNA-(guanosine-N2)-methyltransferase is a non-snRNP cytoplasmic protein that requires a binding site on the Sm core domain. Plessel, G., Fischer, U., Lührmann, R. Mol. Cell. Biol. (1994) [Pubmed]
  20. Effect of iodoacetate on the bone marrow immunocompetence of AKR mice. Rheins, M.S., Filppi, J.A., Moore, V.S. Cancer Res. (1975) [Pubmed]
  21. Use of biochemical lesions for selection of human cells with hybrid cytoplasms. Wright, W.E., Hayflick, L. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
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  23. Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: evidence for gratuitous inducers. Durnam, D.M., Palmiter, R.D. Mol. Cell. Biol. (1984) [Pubmed]
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  34. Lipid order in hepatocyte plasma membrane blebs during ATP depletion measured by digitized video fluorescence polarization microscopy. Florine-Casteel, K., Lemasters, J.J., Herman, B. FASEB J. (1991) [Pubmed]
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