Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CLPTM1 - cleft lip and palate associated...

Homo sapiens

Synonyms: Cleft lip and palate transmembrane protein 1

Rossi, M.R. et al., Endo, M. et al., Yoshiura, K. et al., Turhani, D. et al.

Turhani, Item, Watzinger, Sinko, Watzinger, Lauer, Ewers,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CLPTM1

One clone was homologous to a gene encoding human cleft lip and palate associated transmembrane protein (CLPTM1) like protein, and the other clone did not show a significant similarity to any genes deposited in the public database [1].
Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis [2].

High impact information on CLPTM1

Homozygous mutations were found in the synaptojanin 2 (SYNJ2) and the cleft lip and palate CLPTM1 genes [2].
Exons 2-14 of the CLPTM1 and exons 1-6 of the PVRL1 gene were analysed by a direct sequencing method using DNA extracted from whole blood [3].

Analytical, diagnostic and therapeutic context of CLPTM1

This gene, CLPTM1, was ubiquitously expressed on Northern blots containing RNA from adult tissues and in whole-mount in situ hybridization of day 10 to 12 mouse embryos [4].

References

Generation of 919 expressed sequence tags from immature flower buds and gene expression analysis using expressed sequence tags in the model plant Lotus japonicus. Endo, M., Hakozaki, H., Kokubun, T., Masuko, H., Takahata, Y., Tsuchiya, T., Higashitani, A., Tabata, S., Watanabe, M. Genes Genet. Syst. (2002) [Pubmed]
Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis. Rossi, M.R., Hawthorn, L., Platt, J., Burkhardt, T., Cowell, J.K., Ionov, Y. Cancer Genet. Cytogenet. (2005) [Pubmed]
Mutation analysis of CLPTM 1 and PVRL 1 genes in patients with non-syndromic clefts of lip, alveolus and palate. Turhani, D., Item, C.B., Watzinger, E., Sinko, K., Watzinger, F., Lauer, G., Ewers, R. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (2005) [Pubmed]
Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate. Yoshiura, K., Machida, J., Daack-Hirsch, S., Patil, S.R., Ashworth, L.K., Hecht, J.T., Murray, J.C. Genomics (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP007926	Anopheles gambiae str. PEST
AT5G23575	Arabidopsis thaliana
AT5G08500	Arabidopsis thaliana
CLPTM1	Bos taurus
R166.2	Caenorhabditis elegans
C36B7.6	Caenorhabditis elegans
CLPTM1	Canis lupus familiaris
clptm1	Danio rerio
CG3702	Drosophila melanogaster
CLPTM1	Macaca mulatta
Clptm1	Mus musculus
Os04g0441900	Oryza sativa Japonica Group
CLPTM1	Pan troglodytes
Clptm1	Rattus norvegicus
clptm1	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.