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Gene Review:

GGTA2P - glycoprotein, alpha-galactosyltransferase...

Homo sapiens

Synonyms: GGTA1P, GLYT2L, GLYT3, HGT2

Shaper, N.L. et al., Koike, C. et al., Joziasse, D.H. et al.

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High impact information on GGTA1P

One such locus, GGTA1P, a processed (intronless) pseudogene (PPG), is present in platyrrhines, i.e., New World monkeys, and catarrhines but not in prosimians [1].
To establish that these sequences represent a human homologue of alpha 1----3-galactosyltransferase, we have used the bovine cDNA as a probe to isolate two nonoverlapping clones (HGT-2 and HGT-10) from a human genomic DNA library [2].
We have now established that the former sequence (GGTA1P) is localized to 12q14-q15 and the latter sequence (GGTA1) is localized to 9q33-q34 [corrected] [3].

Biological context of GGTA1P

Assignment of two human alpha-1,3-galactosyltransferase gene sequences (GGTA1 and GGTA1P) to chromosomes 9q33-q34 and 12q14-q15 [3].

References

Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Koike, C., Uddin, M., Wildman, D.E., Gray, E.A., Trucco, M., Starzl, T.E., Goodman, M. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
Characterization of an alpha 1----3-galactosyltransferase homologue on human chromosome 12 that is organized as a processed pseudogene. Joziasse, D.H., Shaper, J.H., Jabs, E.W., Shaper, N.L. J. Biol. Chem. (1991) [Pubmed]
Assignment of two human alpha-1,3-galactosyltransferase gene sequences (GGTA1 and GGTA1P) to chromosomes 9q33-q34 and 12q14-q15. Shaper, N.L., Lin, S.P., Joziasse, D.H., Kim, D.Y., Yang-Feng, T.L. Genomics (1992) [Pubmed]

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