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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dme  -  malic enzyme

Sinorhizobium meliloti 1021

 
 
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Disease relevance of dme

  • Thus, expression of a DME C-terminal deletion derivative or the Escherichia coli NAD(+)-dependent malic enzyme (sfcA), both of which lack the PTA-like region, restored wild-type N(2) fixation to a dme mutant [1].
  • The wild-type NAD(+)-dependent malic enzyme (dme) gene of Rhizobium (now Sinorhizobium) meliloti was cloned and localized to a 3.1 kb region isolated on the cosmid pTH69 [2].
 

High impact information on dme

  • In an otherwise wild-type background, the dme mutations did not alter the carbon utilization phenotype; however, nodules induced by these mutants failed to fix N2 [3].
  • Three independent transposon-induced mutants of R. meliloti which lacked NAD+ malic enzyme activity (dme-) but retained NADP+ malic enzyme activity were isolated [3].
  • The tme gene was placed under the control of the dme promoter, and despite elevated levels of TME within bacteroids, no symbiotic nitrogen fixation occurred in dme mutant strains [1].
 

Other interactions of dme

  • Conversely, expression of dme from the tme promoter resulted in a large reduction in DME activity and symbiotic N(2) fixation [1].

References

  1. Malic Enzyme Cofactor and Domain Requirements for Symbiotic N2 Fixation by Sinorhizobium meliloti. Mitsch, M.J., Cowie, A., Finan, T.M. J. Bacteriol. (2007) [Pubmed]
  2. Properties of NAD(+)- and NADP(+)-dependent malic enzymes of Rhizobium (Sinorhizobium) meliloti and differential expression of their genes in nitrogen-fixing bacteroids. Driscoll, B.T., Finan, T.M. Microbiology (Reading, Engl.) (1997) [Pubmed]
  3. NAD(+)-dependent malic enzyme of Rhizobium meliloti is required for symbiotic nitrogen fixation. Driscoll, B.T., Finan, T.M. Mol. Microbiol. (1993) [Pubmed]
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