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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cask  -  calcium/calmodulin-dependent serine...

Mus musculus

Synonyms: Calcium/calmodulin-dependent serine protein kinase, DXPri1, DXRib1, LIN-2, Pals3, ...
 
 
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Disease relevance of Cask

  • The importance of mLin-2/CASK in mammalian development is demonstrated by the fact that mutations in mLin-2/CASK or SAP97, another MAGUK protein, lead to cleft palate in mice [1].
 

High impact information on Cask

  • Our data identify evolutionarily conserved protein-protein interaction domains that link mLin-2/CASK to SAP97 and account for their common phenotype when mutated in mice [1].
  • In this report, we further define the binding of the L27C domain of mLin-2/CASK to the L27 domain of mLin-7 and identify the binding partner for L27N of mLin-2/CASK [1].
  • In Caenorhabditis elegans, a complex of three PDZ proteins, LIN-2/7/10, mediates basolateral targeting of a receptor tyrosine kinase [2].
  • Here, we report that X11alpha directly binds to the mammalian homologue of Lin-2 (mLin-2), also known as CASK [3].
 

Other interactions of Cask

  • This binding is mediated by direct interaction between the Calmodulin Kinase II (CKII)-like domain of mLin-2 and the amino terminus of X11alpha [3].
  • Furthermore, we can detect direct interactions between mLin-2 and mammalian Lin-7 (mLin-7) [3].

References

  1. A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Lee, S., Fan, S., Makarova, O., Straight, S., Margolis, B. Mol. Cell. Biol. (2002) [Pubmed]
  2. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice. Misawa, H., Kawasaki, Y., Mellor, J., Sweeney, N., Jo, K., Nicoll, R.A., Bredt, D.S. J. Biol. Chem. (2001) [Pubmed]
  3. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. Borg, J.P., Straight, S.W., Kaech, S.M., de Taddéo-Borg, M., Kroon, D.E., Karnak, D., Turner, R.S., Kim, S.K., Margolis, B. J. Biol. Chem. (1998) [Pubmed]
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