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Gene Review

CASK  -  CASK ortholog

Drosophila melanogaster

Synonyms: CAKI, CAMGUK, CG13412, CG13413, CG6703, ...
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Disease relevance of Caki

  • Constitutively expressed Caki protein is enzymatically active since it causes a 3-fold increase in the level of the Rous sarcoma virus long terminal repeat (RSV LTR) promoter in a co-transfusion assay [1].

High impact information on Caki


Biological context of Caki


Anatomical context of Caki

  • The transient cmg transcription in midgut and Malpighian tubules may suggest a potential function in cell junction formation and in epithelial tissue patterning [3].
  • Drosophila Camguk (Cmg) is a member of the CAMGUK subfamily of the MAGUK family of proteins which are localized at cell junction and other plasma membrane specialized regions, from worms to mammals [3].
  • In addition, a high transcriptional level was detected in the eye imaginal discs and in the adult retina, demonstrating a specific and continuous expression of cmg in neuroblasts and photoreceptor neurons, from the onset of cytodifferentiation [3].
  • Coexpression of CMG with EAG in Xenopus oocytes results in a more than twofold average increase in EAG whole-cell conductance [4].
  • Both CMG and phosphorylation of T787 increase the surface expression of EAG channels, and in COS-7 cells, EAG recruits CMG to the plasma membrane [4].

Other interactions of Caki

  • The protein structure of Cmg, as the other CAMGUK proteins, is characterized by only one PDZ domain and an additional CaM kinase domain, similar to CaMKII [3].


  1. A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed. Martin, J.R., Ollo, R. EMBO J. (1996) [Pubmed]
  2. Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation. Lu, C.S., Hodge, J.J., Mehren, J., Sun, X.X., Griffith, L.C. Neuron (2003) [Pubmed]
  3. The CASK/Lin-2 Drosophila homologue, Camguk, could play a role in epithelial patterning and in neuronal targeting. Lopes, C., Gassanova, S., Delabar, J.M., Rachidi, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Camguk/CASK enhances Ether-á-go-go potassium current by a phosphorylation-dependent mechanism. Marble, D.D., Hegle, A.P., Snyder, E.D., Dimitratos, S., Bryant, P.J., Wilson, G.F. J. Neurosci. (2005) [Pubmed]
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