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Gene Review

Apba1  -  amyloid beta (A4) precursor protein...

Mus musculus

Synonyms: 6430513E09Rik, Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Lin-10, Mint, ...
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High impact information on Apba1

  • The MALS/Veli-CASK-Mint-1 complex of PDZ proteins occurs on both sides of the synapse and has the potential to link transsynaptic adhesion molecules to the cytoskeleton [1].
  • Our data indicate that Mints 1 and 2 perform redundant synaptic functions that become apparent in Mint 1-deficient mice in inhibitory interneurons because these neurons selectively express higher levels of Mint 1 than Mint 2 [2].
  • We find that Mints 1 and 2 are similarly expressed in most neurons except for inhibitory interneurons that contain selectively high levels of Mint 1 [2].
  • In electrophysiological recordings in the hippocampus, we observed no changes in short- or long-term synaptic plasticity in excitatory synapses from Mint 1-deficient mice and detected no alterations in the ratio of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) to N-methyl-d-aspartate (NMDA) receptor-mediated synaptic currents [2].
  • Thus the Mint 1-CASK complex is not required for AMPA- and NMDA-receptor functions or for synaptic plasticity in excitatory synapses [2].

Biological context of Apba1


Anatomical context of Apba1


Associations of Apba1 with chemical compounds

  • In inhibitory synapses, however, we uncovered an approximately 3-fold increase in presynaptic paired-pulse depression, suggesting that deletion of Mint 1 impairs the regulation of gamma-aminobutyric acid release [2].

Physical interactions of Apba1

  • Here, we report that X11alpha directly binds to the mammalian homologue of Lin-2 (mLin-2), also known as CASK [10].

Other interactions of Apba1

  • This binding is mediated by direct interaction between the Calmodulin Kinase II (CKII)-like domain of mLin-2 and the amino terminus of X11alpha [10].
  • In mouse brain, we have identified a heterotrimeric complex that contains mLin-2, mLin-7, and X11alpha and that is likely important for the localization of proteins in polarized cells [10].
  • Mint1, but not Mint2 mRNA was abundant in the substantia nigra pars compacta [7].


  1. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. Olsen, O., Moore, K.A., Fukata, M., Kazuta, T., Trinidad, J.C., Kauer, F.W., Streuli, M., Misawa, H., Burlingame, A.L., Nicoll, R.A., Bredt, D.S. J. Cell Biol. (2005) [Pubmed]
  2. A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Ho, A., Morishita, W., Hammer, R.E., Malenka, R.C., Sudhof, T.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice. Mori, A., Okuyama, K., Horie, M., Taniguchi, Y., Wadatsu, T., Nishino, N., Shimada, Y., Miyazawa, N., Takeda, S., Niimi, M., Kyushiki, H., Kondo, M., Mitsumoto, Y. Neurosci. Res. (2002) [Pubmed]
  4. Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. Ho, A., Morishita, W., Atasoy, D., Liu, X., Tabuchi, K., Hammer, R.E., Malenka, R.C., S??dhof, T.C. J. Neurosci. (2006) [Pubmed]
  5. Mapping of recombinant retrovirus integration sites that cause expression of the viral genome in murine embryonal carcinoma cells. Taketo, M., Howard, T.A., Seldin, M.F. Mamm. Genome (1992) [Pubmed]
  6. Molecular cloning and characterization of Pals, proteins associated with mLin-7. Kamberov, E., Makarova, O., Roh, M., Liu, A., Karnak, D., Straight, S., Margolis, B. J. Biol. Chem. (2000) [Pubmed]
  7. Neuronal expression of mint1 and mint2, novel multimodular proteins, in adult murine brain. Nakajima, Y., Okamoto, M., Nishimura, H., Obata, K., Kitano, H., Sugita, M., Matsuyama, T. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  8. Changes in mint1, a novel synaptic protein, after transient global ischemia in mouse hippocampus. Nishimura, H., Matsuyama, T., Obata, K., Nakajima, Y., Kitano, H., Sugita, M., Okamoto, M. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  9. Ultrastructural localization of mint1 at synapses in mouse hippocampus. Okamoto, M., Matsuyama, T., Sugita, M. Eur. J. Neurosci. (2000) [Pubmed]
  10. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. Borg, J.P., Straight, S.W., Kaech, S.M., de Taddéo-Borg, M., Kroon, D.E., Karnak, D., Turner, R.S., Kim, S.K., Margolis, B. J. Biol. Chem. (1998) [Pubmed]
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