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Gene Review:

sat - streptothricin acetyltransferase

Escherichia coli

Horinouchi, S. et al., Zähringer, U. et al., Jacob, J. et al.

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Disease relevance of sat

By addition of promoter signals and a synthetic ribosome-binding (Shine-Dalgarno) sequence at an appropriate position upstream of the STAT translational start codon, the STAT gene confers streptothricin resistance on Escherichia coli and Bacillus subtilis [1].
Nucleotide sequence of the streptothricin acetyltransferase gene from Streptomyces lavendulae and its expression in heterologous hosts [1].
Characterization of the sat4 gene encoding a streptothricin acetyltransferase in Campylobacter coli BE/G4 [2].

High impact information on sat

Another open reading frame located just upstream of the STAT gene was detected and contains a region bearing a strong resemblance to DNA-binding domains which are conserved in known DNA-binding proteins [1].
High-resolution S1 nuclease protection mapping suggests that transcription initiates at or near the adenine residue which is the first position of the translational initiation triplet (AUG) of STAT [1].
Escherichia coli strains harbouring the plasmid pIE636 are able to synthesize acetylcoenzyme A: streptothricin acetyltransferase (ACSAT) [3].

References

Nucleotide sequence of the streptothricin acetyltransferase gene from Streptomyces lavendulae and its expression in heterologous hosts. Horinouchi, S., Furuya, K., Nishiyama, M., Suzuki, H., Beppu, T. J. Bacteriol. (1987) [Pubmed]
Characterization of the sat4 gene encoding a streptothricin acetyltransferase in Campylobacter coli BE/G4. Jacob, J., Evers, S., Bischoff, K., Carlier, C., Courvalin, P. FEMS Microbiol. Lett. (1994) [Pubmed]
Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase of Escherichia coli: location of the acetyl group. Zähringer, U., Voigt, W., Seltmann, G. FEMS Microbiol. Lett. (1993) [Pubmed]

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