The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-00JB7A     [5-(6-aminopurin-9-yl)-2- [[[[3-[2-(2...

Synonyms: A7925_SIGMA, AR-1H5727, AC1L18NR, AC1Q68Z5, 72-89-9, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of acetyl-CoA

  • Thus, acetylcoenzyme A binding to type II E. coli citrate synthase would require substantial structural shifts and a concerted refolding of the polypeptide chain to form an appropriate binding subsite [1].
  • These data suggest that acetylator genotype-dependent expression of AcCoA-dependent N-acetyltransferase activity in extrahepatic tissues may play an important role in hereditary predisposition to toxicity and/or carcinogenesis in extrahepatic organs following exposure to arylamine drugs and foreign chemicals [2].

High impact information on acetyl-CoA

  • RbAp48 lowered the K(m) of CBP histone acetylase activity and facilitated p300-mediated in vitro transcription of a chromatinized template in the presence of acetylcoenzyme A [3].
  • We report the molecular cloning and sequence of the cDNA coding for the biotin-containing subunit of the chloroplastic acetylcoenzyme A (CoA) carboxylase (ACCase) of Arabidopsis thaliana (CAC1) [4].
  • The contribution of exogenous acetate to acetylcoenzyme A was nearly equal in skeletal muscle and heart in vivo (83-87%, measured in tissue extracts), comparable with earlier perfused heart studies in which acetate was the sole available substrate [5].
  • The inhibition of ChA by both alpha- and beta-NETA was noncompetitive with acetylcoenzyme A or choline as the variable substrate [6].
  • However, the reduction in the enzymatic affinity constant and its smaller change following in vitro stimulation suggest that alterations in the affinity of acetyltransferase for acetylcoenzyme A (CoA) and in the regulation of enzyme activity may be occurring during acute asthma [7].

Biological context of acetyl-CoA


Anatomical context of acetyl-CoA


Associations of acetyl-CoA with other chemical compounds


Gene context of acetyl-CoA


Analytical, diagnostic and therapeutic context of acetyl-CoA


  1. Comparative analysis of folding and substrate binding sites between regulated hexameric type II citrate synthases and unregulated dimeric type I enzymes. Nguyen, N.T., Maurus, R., Stokell, D.J., Ayed, A., Duckworth, H.W., Brayer, G.D. Biochemistry (2001) [Pubmed]
  2. Extrahepatic expression of N-acetylator genotype in the inbred hamster. Hein, D.W., Kirlin, W.G., Ogolla, F., Trinidad, A. Drug Metab. Dispos. (1987) [Pubmed]
  3. Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Zhang, Q., Vo, N., Goodman, R.H. Mol. Cell. Biol. (2000) [Pubmed]
  4. Molecular cloning and characterization of the cDNA coding for the biotin-containing subunit of the chloroplastic acetyl-coenzyme A carboxylase. Choi, J.K., Yu, F., Wurtele, E.S., Nikolau, B.J. Plant Physiol. (1995) [Pubmed]
  5. Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo. Szczepaniak, L., Babcock, E.E., Malloy, C.R., Sherry, A.D. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1996) [Pubmed]
  6. 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase. Sastry, B.V., Jaiswal, N., Owens, L.K., Janson, V.E., Moore, R.D. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  7. Lyso-PAF acetyltransferase activity in neutrophils of patients during acute asthma and after recovery. Misso, N.L., Gillon, R.L., Stewart, G.A., Thompson, P.J. Eur. Respir. J. (1996) [Pubmed]
  8. Mechanisms of toxicity, clinical features, and management of acute chlorophenoxy herbicide poisoning: a review. Bradberry, S.M., Watt, B.E., Proudfoot, A.T., Vale, J.A. J. Toxicol. Clin. Toxicol. (2000) [Pubmed]
  9. Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase of Escherichia coli: location of the acetyl group. Zähringer, U., Voigt, W., Seltmann, G. FEMS Microbiol. Lett. (1993) [Pubmed]
  10. Partial purification and characterization of histidine acetyltransferase in brain of Nile tilapia (Oreochromis niloticus). Yamada, S., Tanaka, Y., Furuichi, M. Biochim. Biophys. Acta (1995) [Pubmed]
  11. Utilization of volatile fatty acide in ruminants. IV. Purification of acetylcoenzyme A synthetase from mitochondria of lactating goat mammary gland. Cook, R.M., Simon, S., Ricks, C.A. J. Agric. Food Chem. (1975) [Pubmed]
  12. Effect of the source of dietary fat on postweaning lipogenesis in lean and fat pigs. Freire, J.P., Mourot, J., Cunha, L.F., Almeida, J.A., Aumaitre, A. Ann. Nutr. Metab. (1998) [Pubmed]
  13. Acetylcoenzyme A and the synthesis of acetylcholine in neurones: review of recent progress. Tucek, S. Gen. Physiol. Biophys. (1983) [Pubmed]
  14. Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. Libby, P.R., Ganis, B., Bergeron, R.J., Porter, C.W. Arch. Biochem. Biophys. (1991) [Pubmed]
  15. Molecular evidence for the aerobic expression of nifJ, encoding pyruvate:ferredoxin oxidoreductase, in cyanobacteria. Schmitz, O., Gurke, J., Bothe, H. FEMS Microbiol. Lett. (2001) [Pubmed]
  16. Characterization of Bradyrhizobium japonicum pcaBDC genes involved in 4-hydroxybenzoate degradation. Lorite, M.J., Sanjuan, J., Velasco, L., Olivares, J., Bedmar, E.J. Biochim. Biophys. Acta (1998) [Pubmed]
  17. Direct inhibition of choline acetyltransferase activity by a monoclonal antibody raised against the plasma membrane of cholinergic nerve terminals. Eder-Colli, L., Froment, Y., Monsurro, M.R. Brain Res. (1989) [Pubmed]
  18. Purification and characterization of acetylcoenzyme A: deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus. Power, R., Kurz, W.G., De Luca, V. Arch. Biochem. Biophys. (1990) [Pubmed]
  19. 1(2-benzoylethyl)pyridinium chloride: a new potent and selective inhibitor of bovine brain and human placental choline acetyltransferase. Choudhuri, M.S., Chaturvedi, A.K. Brain Res. Bull. (1991) [Pubmed]
  20. Dietary protein source affects lipid metabolism in the European seabass (Dicentrarchus labrax). Dias, J., Alvarez, M.J., Arzel, J., Corraze, G., Diez, A., Bautista, J.M., Kaushik, S.J. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2005) [Pubmed]
  21. Immobilization of acetylcoenzyme A synthetase and the preparation of an enzyme reactor for the synthesis of [11C]acetylcoenzyme A. Mannens, G., Slegers, G., Lambrecht, R., Claeys, A. Biochim. Biophys. Acta (1988) [Pubmed]
WikiGenes - Universities