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Gene Review:

yscF - YscF

Yersinia enterocolitica W22703

Torruellas, J. et al., Allaoui, A. et al., Davis, A.J. et al.

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Disease relevance of yscF

Mutations in the Yersinia pseudotuberculosis Type III Secretion System Needle Protein, YscF, That Specifically Abrogate Effector Translocation into Host Cells [1].

High impact information on yscF

Alanine-scanning mutagenesis was used to identify YscF mutants that secrete virulence proteins in the presence and absence of calcium and prior to contact with a eukaryotic cell [2].
Interestingly, one of the YscF mutants that exhibited constitutive T3S was unable to translocate secreted proteins across the eukaryotic plasma membrane [2].
The yscE, FG, I, J and K mutants were defective in Yop secretion and independent of Ca2+ (CI) for their growth at 37 degrees C. Substitution of the 12 N-terminal amino-acid residues of YscF impaired secretion of YopB and YopD only and led also to a CI phenotype [3].

References

Mutations in the Yersinia pseudotuberculosis Type III Secretion System Needle Protein, YscF, That Specifically Abrogate Effector Translocation into Host Cells. Davis, A.J., Mecsas, J. J. Bacteriol. (2007) [Pubmed]
The Yersinia pestis type III secretion needle plays a role in the regulation of Yop secretion. Torruellas, J., Jackson, M.W., Pennock, J.W., Plano, G.V. Mol. Microbiol. (2005) [Pubmed]
Mutational analysis of the Yersinia enterocolitica virC operon: characterization of yscE, F, G, I, J, K required for Yop secretion and yscH encoding YopR. Allaoui, A., Schulte, R., Cornelis, G.R. Mol. Microbiol. (1995) [Pubmed]

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