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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

acrR  -  AcrAB operon transcriptional repressor

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
 
 
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Disease relevance of acrR

 

High impact information on acrR

  • Thus, this study underlines the role of an acrR mutation, in addition to the mutation in gyrA, in the fluoroquinolone and multidrug resistance phenotype of S [1].
  • A mutation in acrR, the local repressor of acrAB, was found for two ciprofloxacin-resistant selected-mutants, leading to duplication of amino acids Ile75 and Glu76 [1].
 

Analytical, diagnostic and therapeutic context of acrR

  • The acrR mutation also contributed to acrAB overexpression as shown by RT-PCR [1].

References

  1. Role of an acrR mutation in multidrug resistance of in vitro-selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium. Olliver, A., Vallé, M., Chaslus-Dancla, E., Cloeckaert, A. FEMS Microbiol. Lett. (2004) [Pubmed]
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