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MeSH Review

Drug Resistance, Multiple

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Disease relevance of Drug Resistance, Multiple


High impact information on Drug Resistance, Multiple


Chemical compound and disease context of Drug Resistance, Multiple


Biological context of Drug Resistance, Multiple


Anatomical context of Drug Resistance, Multiple


Associations of Drug Resistance, Multiple with chemical compounds


Gene context of Drug Resistance, Multiple


Analytical, diagnostic and therapeutic context of Drug Resistance, Multiple


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  2. Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily. Berkower, C., Michaelis, S. EMBO J. (1991) [Pubmed]
  3. High expression of the mdr3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia. Sonneveld, P., Nooter, K., Burghouts, J.T., Herweijer, H., Adriaansen, H.J., van Dongen, J.J. Blood (1992) [Pubmed]
  4. Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis. Modlich, U., Kustikova, O.S., Schmidt, M., Rudolph, C., Meyer, J., Li, Z., Kamino, K., von Neuhoff, N., Schlegelberger, B., Kuehlcke, K., Bunting, K.D., Schmidt, S., Deichmann, A., von Kalle, C., Fehse, B., Baum, C. Blood (2005) [Pubmed]
  5. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Hooijberg, J.H., Broxterman, H.J., Kool, M., Assaraf, Y.G., Peters, G.J., Noordhuis, P., Scheper, R.J., Borst, P., Pinedo, H.M., Jansen, G. Cancer Res. (1999) [Pubmed]
  6. Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. Norris, M.D., Bordow, S.B., Marshall, G.M., Haber, P.S., Cohn, S.L., Haber, M. N. Engl. J. Med. (1996) [Pubmed]
  7. Gain of function mutations in p53. Dittmer, D., Pati, S., Zambetti, G., Chu, S., Teresky, A.K., Moore, M., Finlay, C., Levine, A.J. Nat. Genet. (1993) [Pubmed]
  8. A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein. Cutting, G.R., Kasch, L.M., Rosenstein, B.J., Zielenski, J., Tsui, L.C., Antonarakis, S.E., Kazazian, H.H. Nature (1990) [Pubmed]
  9. A multidrug resistance transporter/serine protease gene is required for prestalk specialization in Dictyostelium. Shaulsky, G., Kuspa, A., Loomis, W.F. Genes Dev. (1995) [Pubmed]
  10. Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics. Burt, R.K., Thorgeirsson, S.S. J. Natl. Cancer Inst. (1988) [Pubmed]
  11. Cephalosporin therapy for salmonellosis. Questions of efficacy and cross resistance with ampicillin. Cherubin, C.E., Eng, R.H., Smith, S.M., Goldstein, E.J. Arch. Intern. Med. (1986) [Pubmed]
  12. Breast cancer resistance protein in drug resistance of primitive CD34+38- cells in acute myeloid leukemia. Raaijmakers, M.H., de Grouw, E.P., Heuver, L.H., van der Reijden, B.A., Jansen, J.H., Scheper, R.J., Scheffer, G.L., de Witte, T.J., Raymakers, R.A. Clin. Cancer Res. (2005) [Pubmed]
  13. Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma. Belpomme, D., Gauthier, S., Pujade-Lauraine, E., Facchini, T., Goudier, M.J., Krakowski, I., Netter-Pinon, G., Frenay, M., Gousset, C., Marié, F.N., Benmiloud, M., Sturtz, F. Ann. Oncol. (2000) [Pubmed]
  14. Nonsteroidal anti-inflammatory drugs potentiate 1-methyl-4-phenylpyridinium (MPP+)-induced cell death by promoting the intracellular accumulation of MPP+ in PC12 cells. Morioka, N., Kumagai, K., Morita, K., Kitayama, S., Dohi, T. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  15. Flow cytometric analysis of Hoechst 33342 uptake as an indicator of multi-drug resistance in human lung cancer. Morgan, S.A., Watson, J.V., Twentyman, P.R., Smith, P.J. Br. J. Cancer (1989) [Pubmed]
  16. Consequences of altered isoprenylation targets on a-factor export and bioactivity. Caldwell, G.A., Wang, S.H., Naider, F., Becker, J.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Level of minimal residual disease after consolidation therapy predicts outcome in acute myeloid leukemia. Venditti, A., Buccisano, F., Del Poeta, G., Maurillo, L., Tamburini, A., Cox, C., Battaglia, A., Catalano, G., Del Moro, B., Cudillo, L., Postorino, M., Masi, M., Amadori, S. Blood (2000) [Pubmed]
  18. Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice. Bunting, K.D., Galipeau, J., Topham, D., Benaim, E., Sorrentino, B.P. Blood (1998) [Pubmed]
  19. Chromosome 7 long arm deletion in myeloid disorders: a narrow breakpoint region in 7q22 defined by molecular mapping. Kere, J., Ruutu, T., Davies, K.A., Roninson, I.B., Watkins, P.C., Winqvist, R., de la Chapelle, A. Blood (1989) [Pubmed]
  20. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Belinsky, M.G., Chen, Z.S., Shchaveleva, I., Zeng, H., Kruh, G.D. Cancer Res. (2002) [Pubmed]
  21. Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia. Rost, D., König, J., Weiss, G., Klar, E., Stremmel, W., Keppler, D. Gastroenterology (2001) [Pubmed]
  22. Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae. Kuchler, K., Thorner, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  23. Overexpression and biosynthesis of CD4 in Chinese hamster ovary cells: coamplification using the multiple drug resistance gene. König, R., Ashwell, G., Hanover, J.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  24. Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin. Sherwood, S.W., Assaraf, Y.G., Molina, A., Schimke, R.T. Cancer Res. (1990) [Pubmed]
  25. Regulation of multidrug resistance 2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes. Gupta, S., Todd Stravitz, R., Pandak, W.M., Müller, M., Reno Vlahcevic, Z., Hylemon, P.B. Hepatology (2000) [Pubmed]
  26. Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine. Akiyama, S., Shiraishi, N., Kuratomi, Y., Nakagawa, M., Kuwano, M. J. Natl. Cancer Inst. (1986) [Pubmed]
  27. Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance. Rice, G.C., Ling, V., Schimke, R.T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. Estradiol-inducible squelching and cell growth arrest by a chimeric VP16-estrogen receptor expressed in Saccharomyces cerevisiae: suppression by an allele of PDR1. Gilbert, D.M., Heery, D.M., Losson, R., Chambon, P., Lemoine, Y. Mol. Cell. Biol. (1993) [Pubmed]
  29. Reversal of Vinca alkaloid resistance but not multiple drug resistance in human leukemic cells by verapamil. Beck, W.T., Cirtain, M.C., Look, A.T., Ashmun, R.A. Cancer Res. (1986) [Pubmed]
  30. Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase. Zhang, X., Moye-Rowley, W.S. J. Biol. Chem. (2001) [Pubmed]
  31. PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. Balzi, E., Wang, M., Leterme, S., Van Dyck, L., Goffeau, A. J. Biol. Chem. (1994) [Pubmed]
  32. New regulators of drug sensitivity in the family of yeast zinc cluster proteins. Akache, B., Turcotte, B. J. Biol. Chem. (2002) [Pubmed]
  33. AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. Alarco, A.M., Balan, I., Talibi, D., Mainville, N., Raymond, M. J. Biol. Chem. (1997) [Pubmed]
  34. ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins. Rebbeor, J.F., Connolly, G.C., Dumont, M.E., Ballatori, N. J. Biol. Chem. (1998) [Pubmed]
  35. Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. Jansen, P.L., Strautnieks, S.S., Jacquemin, E., Hadchouel, M., Sokal, E.M., Hooiveld, G.J., Koning, J.H., De Jager-Krikken, A., Kuipers, F., Stellaard, F., Bijleveld, C.M., Gouw, A., Van Goor, H., Thompson, R.J., Müller, M. Gastroenterology (1999) [Pubmed]
  36. Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism. Zatelli, M.C., Luchin, A., Piccin, D., Tagliati, F., Bottoni, A., Vignali, C., Bondanelli, M., degli Uberti, E.C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  37. Specific therapy of digoxin intoxication in dogs by hybrid kidney overexpressing multidrug resistance protein. Tsuruoka, S., Nishiki, K., Sugimoto, K., Suzuki, M., Imai, M., Fujimura, A. Kidney Int. (2002) [Pubmed]
  38. P-glycoprotein expression in bladder cancer. Park, J., Shinohara, N., Liebert, M., Noto, L., Flint, A., Grossman, H.B. J. Urol. (1994) [Pubmed]
  39. Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Chen, C., Klaassen, C.D. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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